β-烟酰胺腺嘌呤二核苷酸水化物已用于：制备用于NAD+代谢组学研究的 NAD+ 标准溶液作为MurI 测定反应部分混合物的成分用于谷氨酸消旋酶反应作为显色染色液的成分用于斑马鱼胚胎的染色应用：
烟酰胺腺嘌呤二核苷酸(NAD)是一种必需的辅酶，这一特性令其超越“电子载体”的传统角色，影响各种细胞过程。在细胞生物学中，NAD 是电子传递链中的关键电子受体，促使细胞′的主要能源ATP的生成。这种电子流动维持了基本的细胞维护和复杂信号传导途径。除了能量方面的作用以外，NAD 可用作动态信号传导分子，控制了细胞对多种刺激的反应。NAD浓度的变动会引发DNA修复、基因表达和细胞死亡中的事件，使得细胞适应应激并维持稳态。在生物化学研究中，NAD 是sirtuins、多聚ADP核糖聚合酶和cADP核糖合成酶等酶所必需的辅酶。这些酶的催化活性依赖于NAD+，它们影响多个过程，如蛋白质脱乙酰、DNA修复和细胞信号传导。在代谢组学中，NAD在代谢途径中起到关键作用，这一点令其成为全面理解细胞代谢的关键焦点。NAD 参与其它复杂细胞过程，可作为ADP-核糖基化的底物—，核糖基化是影响蛋白质功能的翻译后修饰。 它也可作为环ADP核糖的前体，环ADP核糖是涉及钙动员 (calcium mobilization)和细胞通讯的第二信使分子。NAD研究为多个领域（包括老化）带来希望，目前研究人员在积极进行老化研究。研究也探索了它对神经退行性疾病和代谢失调的影响。
Nicotinamide adenine dinucleotide (NAD) is a vital coenzyme that transcends its traditional role as an 'electron carrier,' influencing diverse cellular processes. In cell biology, NAD operates as a crucial electron acceptor in the electron transport chain, driving the production of ATP, the cell′s primary energy source. This electron flow sustains basic cellular maintenance and complex signaling pathways. Beyond its energetic role, NAD serves as a dynamic signaling molecule, dictating cellular responses to various stimuli. Fluctuations in NAD concentration trigger events in DNA repair, gene expression, and cell death, allowing cells to adapt to stress and maintain homeostasis.
In biochemical research, NAD emerges as a vital cofactor for enzymes like sirtuins, poly(ADP-ribose) polymerases, and cADP-ribose synthases. These enzymes rely on NAD+ for catalytic activity, influencing processes such as protein deacetylation, DNA repair, and cellular signaling. In metabolomics, NAD plays a key role in metabolic pathways, making it a significant focus for understanding cellular metabolism comprehensively. NAD participates in additional intricate cellular processes, serving as a substrate for ADP-ribosylation—a post-translational modification affecting protein function. It also acts as a precursor for cyclic ADP-ribose, a second messenger molecule involved in calcium mobilization and cell communication. Research on NAD holds promise across various areas, including aging, where its role is actively investigated. Studies also explore its implications in neurodegenerative disorders and metabolic imbalances.
Application:
β-Nicotinamide adenine dinucleotide hydrate has been used:
- to prepare NAD+ standard solution for a study on NAD+ metabolomics
- as a component of MurI assay reaction partial mixture for glutamate racemase reaction
- as a component of a chromogenic staining solution to stain zebrafish embryos
L2525164
危险品化学品经营许可证（带存储）