计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 87 篇同行评审文献引用。
概述
可抑制丝氨酸蛋白酶例如胰蛋白酶(trypsin)和胰凝乳蛋白酶(chymotrypsin)，也可抑制半胱氨酸蛋白酶和乙酰胆碱酯酶。有效浓度为0.1-1mM。抑制丝氨酸蛋白酶，如胰蛋白酶和胰凝乳蛋白酶。 还可抑制半胱氨酸蛋白酶（可通过还原的硫醇可逆）和哺乳动物乙酰胆碱酯酶。 不如DFP有效或具有毒性。 有效浓度0.1-1 mM。 pH 7.5时半衰期 = 1小时。 苯基甲磺酰氟已用于以下应用： · 细胞分级分离。 · 在核蛋白提取中作为补充剂。 · 胆固醇酯酶（CE）和假胆碱酯酶（PCE）抑制剂。 · 在离心之前用于血液的收集以量化血浆ANP的水平。
Information
PMSF PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.
In vitro
Although human trypsin is less susceptible to inhibition by PMSF, PMSF rapidly inactivates purified chymotrypsin from human pancreas. PMSF also rapidly inhibits acetylcholinesterase from human red cells. As an inhibitor of phosphatidylinositol-specific phospholipase C, PMSF treatment at 2 mM almost completely inhibits carbachol-stimulated inositol incorporation into phosphatidylinositol (PI) of longitudinal smooth muscle of guinea pig ileum, while it has no effect on potassium-stimulated inositol incorporation. In contrast to its specific inhibition of carbachol-stimulated phosphoinositide turnover, PMSF produces a transient inhibition of contraction by both carbachol and potassium. PMSF has been shown to inhibit the addition of ethanolamine phosphate to glycosylphosphatidylinositol (GPI) intermediates in Trypanosoma brucei. PMSF also inhibits the acylation of the inositol residue of GPI intermediates in bloodstream form T. brucei. PMSF inhibits ethanolamine phosphate addition and inositol acylation for procyclic forms of T. brucei but not for mammalian HeLa cells. PMSF is the more reactive inactivator of mouse acetylcholinesterase (AChE), as the 8-fold higher BSF concentration is necessary to achieve even a 6-fold slower inactivation than that using PMSF.
In vivo
Intraperitoneal injection of PMSF produces dose-dependent analgesia in Sprague-Dawley rats. PMSF significantly enhances the analgesic effect of beta-endorphin (END) in rats. Mice receiving i.p. injections of PMSF exhibit cannabinoid effects that include antinociception, hypothermia and immobility with ED50 of 86 mg/kg, 224 mg/kg and 206 mg/kg, respectively. Pretreatment with an inactive dose of PMSF (30 mg/kg) enhances the effects of anandamide on tail-flick response (antinociception), spontaneous activity and mobility by 5-, 10- and 8-fold, respectively. Administration of PMSF 12 hours prior to PSP causes complete protection in organophosphorus ester-induced delayed neuropathy (OPIDN) in hens, but PMSF administered 4 hours after PSP potentiates its neurotoxic effects. Pretreatment with PMSF (30 mg/kg, i.p.) prior to an injection of 1 or 10 mg/kg 3H-anandamide results 5 minutes later in enhanced brain levels of anandamide compared to those obtained with 3H-anandamide plus vehicle injection. Pretreatment with PMSF inhibits tri-ortho-cresyl phosphate (TOCP)-induced neurofilament (NF) degradation, and protects hens against the development of organophosphate-induced delayed neuropathy (OPIDN). Administration of PMSF enhances the characteristic cannabimimetic effects of Δ(9)-tetrahydrocannabinol (THC) or anandamide (AEA) in ICR mice, by inhibiting the enzyme fatty acid amide hydrolase.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥98%
规格
英文别名
Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride | phenylmethanesulfonyl fluoride
规格或纯度
10mM in DMSO
英文名称
PMSF
生化机理
PMSF（苯甲基磺酰氟，苄基磺酰氟）是一种不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
EC号
206-350-2
分子类型
小分子
Isomeric SMILES
C1=CC=C(C=C1)CS(=O)(=O)F
UN Number
分子量
174.19
Beilstein号
2088311
Reaxy-Rn
2088311
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2088311&ln=
技术文档
高级数据
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 100 mg/mL (124.53 mM);
沸点
85°C/0.3mmHg
熔点
92-95°C
安全和危险性（GHS）
信号词
危险
危险声明
H301: 吞咽会中毒
H314: 造成严重的皮肤灼伤和眼睛损伤
预防措施声明
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P310: 立即致电解毒中心或医生。
P330: 漱口
P363: 再次使用之前，请清洗受污染的衣物。
P301+P310: 如误吞咽：立即呼叫急救中心/医生。
P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。
P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P405: 密闭存放
P501: 将内容物/容器处理到。。。
WGK Germany
3
RTECS
XT8040000
Merck Index
7542
个人防护装备
Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 K2407003 |
分析证书 | P408676 |
技术文档和文章
防止蛋白沉淀的缓冲液添加剂
目录： 技术文章
如何优化镍琼脂糖微球的缓冲液组分
目录： 技术文章
如何选择最佳蛋白质纯化技术
目录： 技术文章
分子互作实验常见问答
目录： 常见问题(FAQs)
His-Tag Protein Purification: Common Troubleshooting Questions and Practical Solutions
目录： 常见问题(FAQs)
OSF/ASF Dual-Channel Toolbox: Divergent Reactions of Four-Membered Ring Sulfonyl Fluorides, Condition “Knobs,” and Selection Navigation
目录： 技术文章
Protein Tags Demystified: Classification, Properties, and Suitable Experimental Applications
目录： 技术文章
Angiotensin-Converting Enzyme (ACE): A Review of Molecular Features, Catalytic Functions, and Research and Translational Applications
目录： 技术文章
Review of Chymotrypsin: Enzymological Properties, Catalytic Mechanism, and Research Applications
目录： 技术文章
Furin: A Review of Its Structural Features, Substrate Recognition, and Research Applications
目录： 技术文章
Roles of the Carboxypeptidase Family in Protein C-Terminal Processing and Experimental Analysis
目录： 技术文章
SuFEx and Sulfonyl Fluorides: From S(VI)–F Click Ligation Reactions to Covalent Tools in Chemical Biology
目录： 技术文章
Coupling Mechanisms Between Terminal Reducing-Power Allocation in Photosynthetic Electron Transport and Metabolic Demand
目录： 技术文章
What Is Synthetic Biology? The Industrialization Pathway from Upstream Reagent Toolchains to Biomanufacturing Applications
目录： 技术文章
此产品的引用文献
引用文献
| 1. Jiake Yu, Shuying Wang, Jie Yang, Wuxinrui Huang, Beikang Tang, Weijun Peng, Jing Tian. (2023) Exploring the mechanisms of action of Zengye decoction (ZYD) against Sjogren’s syndrome (SS) using network pharmacology and animal experiment. PHARMACEUTICAL BIOLOGY, [PMID:37606264] [10.1080/13880209.2023.2248188] |
| 2. Xiuwen Zheng, Yuxin Zhang, Jian Xu, Xiangyi Li, Huan Wen, Xuguang Zhang, Aixia Liu, Junqing Zhang. (2023) Exploring the Underlying Mechanism of Alpinia officinarum Hance Ameliorating Diabetic Gastroparesis through Combining Network Pharmacology, Molecular Docking, and in Vivo Experimental Verification. Frontiers in Bioscience-Landmark, 28 (8): (164). [PMID:37664921] [10.31083/j.fbl2808164] |
| 3. Yujun Zhao, Xiaotie Wang, Keke Nie. (2023) IRF1 promotes the chondrogenesis of human adipose-derived stem cells through regulating HILPDA. TISSUE & CELL, [PMID:36933274] [10.1016/j.tice.2023.102046] |
| 4. Zhe Chen, Yunxia Wang. (2023) A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes for the detection of telomerase activity. JOURNAL OF CHEMICAL RESEARCH, [10.1177/17475198221139085] |
| 5. Yinxuan Lin, Jiao Yu, Meng Wang, Lingling Wu. (2022) Toxicity of single and combined 4-epianhydrotetracycline and cadmium at environmentally relevant concentrations on the zebrafish embryos (Danio rerio). ENVIRONMENTAL POLLUTION, [PMID:36341832] [10.1016/j.envpol.2022.120543] |
| 6. Huang Yang, Yuan Ding, Zongrui Tong, Xiaohui Qian, Hao Xu, Fenghao Lin, Guoping Sheng, Liangjie Hong, Weilin Wang, Zhengwei Mao. (2022) pH-responsive hybrid platelet membrane-coated nanobomb with deep tumor penetration ability and enhanced cancer thermal/chemodynamic therapy. Theranostics, [PMID:35673566] [10.7150/thno.68996] |
| 7. Weimin Lin, Xianyu Wen, Xuexin Li, Lei Chen, Wei Wei, Lifan Zhang, Jie Chen. (2022) MiR-144 regulates adipogenesis by mediating formation of C/EBPα-FOXO1 protein complex. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:35525196] [10.1016/j.bbrc.2022.04.093] |
| 8. Shi-Hao Mao, Dan-Dan Feng, Xi Wang, Yi-Hui Zhi, Shu Lei, Xi Xing, Rong-Lin Jiang, Jian-Nong Wu. (2021) Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation, normal T-cell expressed and secreted. World Journal of Clinical Cases, [PMID:35004977] [10.12998/wjcc.v9.i34.10451] |
| 9. Sadaf Mahboudi, Kazem Parivar, Zohreh Mazaheri, Shiva Irani. (2021) Mir-106b Cluster Regulates Primordial Germ Cells Differentiation from Human Mesenchymal Stem Cells. Cell Journal, [PMID:34308572] [10.22074/cellj.2021.6836] |
| 10. Yuqiu Zi, Dawei Xu, Cong Li, Fei Qu, Xian-En Zhao. (2021) Aggregation-enhanced emission of metal nanoclusters triggered by peptide self-assembly and application in chymotrypsin inhibitor screening. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2021.130243] |
| 11. Yin Yi-Rui, Sang Peng, Yang Feng-Li, Li Tao, Yang Run-Feng, Liu Hong-Yan, Luo Zong-Long, Li Wen-Jun, Yang Li-Quan. (2020) Characterization of a Cu2+, SDS, alcohol and glucose tolerant GH1 β-glucosidase from Bacillus sp. CGMCC 1.16541. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 113 (10): (1467-1477). [PMID:32748077] [10.1007/s10482-020-01455-w] |
| 12. Xianfei Zhang, Jiuyong Xu, Solange Muhayimana, Hui Xiong, Xuefeng Liu, Qingchun Huang. (2020) Antifungal effects of 3-(2-pyridyl)methyl-2-(4-chlorphenyl) iminothiazolidine against Sclerotinia sclerotiorum. PEST MANAGEMENT SCIENCE, 76 (9): (2978-2985). [PMID:32246520] [10.1002/ps.5843] |
| 13. Mengting Ni, Xing Hu, Deming Gong, Guowen Zhang. (2020) Inhibitory mechanism of vitexin on α-glucosidase and its synergy with acarbose. FOOD HYDROCOLLOIDS, [10.1016/j.foodhyd.2020.105824] |
| 14. Jiang Zhu, Kai Tian, Christopher A. Reilly, Xinghui Qiu. (2019) Capsaicinoid metabolism by the generalist Helicoverpa armigera and specialist H. assulta: Species and tissue differences. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, [PMID:31973854] [10.1016/j.pestbp.2019.11.013] |
| 15. Yiping Chen, Jing Cao, Xiaoxue Jiang, Zhizhen Pan, Nanyan Fu. (2018) A sensitive ratiometric fluorescence probe for chymotrypsin activity and inhibitor screening. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2018.06.021] |
| 16. Li Shan, Yang Zhaoguang, Cao Junfei, Qiu Bo, Li Haipu. (2018) Determination of Metallothionein Isoforms in Fish by Cadmium Saturation Combined with Anion Exchange HPLC-ICP-MS. CHROMATOGRAPHIA, 81 (6): (881-889). [10.1007/s10337-018-3523-3] |
| 17. Yunhua Zhang, Jinyun Ji, Xiao Zhao, Ruoheng Jin, Jianhong Li, Hu Wan. (2017) Expression, purification and enzymatic properties of a β-N-acetylhexosaminidase from brown planthopper, Nilaparvata lugens. JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, [10.1016/j.aspen.2017.10.005] |
| 18. Zhang Hui, Li Mengya, Li Jie, Wang Guangli, Liu Yuan. (2017) Purification and properties of a novel quizalofop-p-ethyl-hydrolyzing esterase involved in quizalofop-p-ethyl degradation by Pseudomonas sp. J-2. Microbial Cell Factories, 16 (1): (1-10). [PMID:28490371] [10.1186/s12934-017-0695-8] |
| 19. Ailing Hui, Shijing Zhu, Huayang Yin, Li Yang, Zheng Zhang, An Zhou, Jian Pan, Wencheng Zhang. (2016) Novel ginkgolide B derivative attenuated the function and expression of P-glycoprotein at the blood–brain barrier, presenting brain-targeting ability. RSC Advances, 6 (37): (31101-31106). [10.1039/C5RA25248B] |
| 20. Tian-Jing Wang, Jing An, Xiao-Hui Chen, Qiu-Di Deng, Liu Yang. (2014) Assessment of Cuscuta chinensis seeds׳ effect on melanogenesis: Comparison of water and ethanol fractions in vitro and in vivo. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:24746484] [10.1016/j.jep.2014.04.016] |
| 21. Xiaobang Liu, Jiaqun Du, Junpeng Sun, Han Wang, Jinyu An, Yingqiao Li, Yu Hu, Shuai Cheng, Huicong Feng, He Tian, Xifan Mei, Yang Qiu, Chao Wu. (2024) Borneol-Functionalized Macrophage Membrane-Encapsulated Mesoporous Selenium Nanoparticles Loaded with Resveratrol for the Treatment of Spinal Cord Injury. ACS Applied Materials & Interfaces, [PMID:39511843] [10.1021/acsami.4c12454] |
| 22. Tengfei Xiong, Mingyue Yu, Jiang Zhu, Kai Tian, Mei Li, Xinghui Qiu. (2024) Functional characterization of Helicoverpa assulta CYP6B6 in insecticide metabolism. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, [PMID:38685236] [10.1016/j.pestbp.2024.105857] |
| 23. Xiaodong Shi, Wei Song, Boyue Jiang, Jie Ma, Wanyang Li, Mingyao Sun, Hongyuan Cui, Wei Chen. (2024) Highland Barley Alleviates High-Fat Diet-Induced Obesity and Liver Injury Through the IRS2/PI3K/AKT Signaling Pathway in Rats. Nutrients, 16 (20): (3518). [PMID:39458511] [10.3390/nu16203518] |
| 24. Gong Zhaoyang, Chen Zhenhao, Li Dachuan, Lu Xiao, Wu Jianwei, Sun Hanqiu, Wang Ximeng, Liu Siyang, Xia Xinlei, Lu Feizhou, Jiang Jianyuan, Sun Chi, Wang Hongli, Zeng Feng, Ma Xiaosheng. (2025) Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration. JOURNAL OF NANOBIOTECHNOLOGY, 23 (1): (1-23). [PMID:39833803] [10.1186/s12951-025-03098-3] |
| 25. Xinqing Shi, Jiaman Liu, Wanqin Zhang, Shinian Zeng, Fan Lin, Haining Wang, Bo Teng. (2024) Mechanism of the wine pomace tannin in hyperpigmentation inhibition: Impact on signaling pathways, cell proliferation, and tyrosinase activity. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39038577] [10.1016/j.ijbiomac.2024.134052] |
| 26. Mengkai Hu, Teng Bao, Zhen Qin, Qiang Wang, Hengwei Zhang, Yujue Wang, Jiajia You, Zhenglian Xue, Rongzhen Zhang, Shang-Tian Yang, Xian Zhang, Zhiming Rao. (2025) Programmable Scaffold-Mediated Assembly Regulation Tool for Dynamic Control of a Multienzyme Biocatalyst. ACS Catalysis, [10.1021/acscatal.4c05420] |
| 27. Gongxi Qiao, Shenglin Li, Xumin Pan, Ping Xie, Ruixi Peng, Xiangrong Huang, Mengyun He, Jianhui Jiang, Xia Chu. (2024) Surgical tumor–derived nanoplatform targets tumor-associated macrophage for personalized postsurgical cancer immunotherapy. Science Advances, 10 (13): [PMID:38536926] [10.1126/sciadv.adk7955] |
| 28. Rongrong He, Ziwei Lv, Yinan Li, Shuchao Ren, Jiaqi Cao, Jun Zhu, Xinrong Zhang, Huimin Wu, Lihao Wan, Ji Tang, Shutong Xu, Xiao-Lin Chen, Zhipeng Zhou. (2024) tRNA-m1A methylation controls the infection of Magnaporthe oryzae by supporting ergosterol biosynthesis. DEVELOPMENTAL CELL, [PMID:39191251] [10.1016/j.devcel.2024.08.002] |
| 29. Cai Jing, Wu Hao, Wang Chenxing, Chen Yujiao, Zhang Dingli, Guan Shiwei, Fu Beilei, Jin Yingli, Qian Cao. (2023) Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease. BMC IMMUNOLOGY, 24 (1): (1-12). [PMID:38066482] [10.1186/s12865-023-00578-9] |
| 30. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian. (2023) Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage. ACS Applied Materials & Interfaces, [PMID:37410709] [10.1021/acsami.3c06838] |
| 31. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun. (2023) The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats. Experimental and Therapeutic Medicine, 25 (5): (1-7). [PMID:37114173] [10.3892/etm.2023.11931] |
| 32. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen. (2023) Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications. CURRENT PHARMACEUTICAL DESIGN, [PMID:36722481] [10.2174/1381612829666230201144029] |
| 33. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu. (2023) Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase. BIOMACROMOLECULES, [PMID:36644840] [10.1021/acs.biomac.2c01350] |
| 34. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao. (2022) An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals. BIOSENSORS & BIOELECTRONICS, [PMID:36529054] [10.1016/j.bios.2022.115013] |
| 35. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge. (2022) Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress. Journal of Environmental Sciences, [PMID:37225375] [10.1016/j.jes.2022.10.029] |
| 36. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin. (2022) Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries). JOURNAL OF THERMAL BIOLOGY, [PMID:36195394] [10.1016/j.jtherbio.2022.103333] |
| 37. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing. (2022) Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells. Evidence-based Complementary and Alternative Medicine, [PMID:35873638] [10.1155/2022/7008907] |
| 38. Zhou Changkai, Gao Jing, Ji Hongyan, Li Wenjing, Xing Xiaomin, Liu Donghua, Guo Qie, Zhou Lihua, Jing Fanbo. (2021) Benzoylaconine Modulates LPS-Induced Responses Through Inhibition of Toll-Like Receptor-Mediated NF-κB and MAPK Signaling in RAW264.7 Cells. INFLAMMATION, 44 (5): (2018-2032). [PMID:34272638] [10.1007/s10753-021-01478-z] |
| 39. Yini Pan, Chenhui Zhang, Ruili Xiao, Lingyi Zhang, Weibing Zhang. (2021) Dual-functionalized magnetic bimetallic metal-organic framework composite for highly specific enrichments of phosphopeptides and glycopeptides. ANALYTICA CHIMICA ACTA, [PMID:33863420] [10.1016/j.aca.2021.338412] |
| 40. Miao Liu, Wenjie Xie, Xinyue Wan, Tao Deng. (2020) Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate‑induced colitis. Experimental and Therapeutic Medicine, 20 (5): (1-1). [PMID:32934675] [10.3892/etm.2020.9138] |
| 41. Guojun Yang, Wei Chen, Haidong Tan, Kuikui Li, Junyan Li, Heng Yin. (2020) Biochemical characterization and evolutionary analysis of a novel pectate lyase from Aspergillus parasiticus. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:32109469] [10.1016/j.ijbiomac.2020.02.279] |
| 42. Yin Yi-Rui, Sang Peng, Xiao Min, Xian Wen-Dong, Dong Zhou-Yan, Liu Lan, Yang Li-Quan, Li Wen-Jun. (2020) Expression and characterization of a cold-adapted, salt- and glucose-tolerant GH1 β-glucosidase obtained from Thermobifida halotolerans and its use in sugarcane bagasse hydrolysis. Biomass Conversion and Biorefinery, 11 (4): (1245-1253). [10.1007/s13399-019-00556-5] |
| 43. Na Liu, Han Zhang, Jinfeng Zhao, Yin Xu, Fei Ge. (2019) Mechanisms of cetyltrimethyl ammonium chloride-induced toxicity to photosystem II oxygen evolution complex of Chlorella vulgaris F1068. JOURNAL OF HAZARDOUS MATERIALS, [PMID:31539660] [10.1016/j.jhazmat.2019.121063] |
| 44. Ruili Xiao, Yini Pan, Jie Li, Lingyi Zhang, Weibing Zhang. (2019) Layer-by-layer assembled magnetic bimetallic metal-organic framework composite for global phosphopeptide enrichment. JOURNAL OF CHROMATOGRAPHY A, [PMID:31182303] [10.1016/j.chroma.2019.05.010] |
| 45. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou. (2019) Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary. Experimental and Therapeutic Medicine, 17 (5): (3501-3508). [PMID:30988730] [10.3892/etm.2019.7352] |
| 46. Juan Wang, Mengmeng Song, Chengguo Hu, Kangbing Wu. (2018) Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs. ANALYTICAL CHEMISTRY, [PMID:29998727] [10.1021/acs.analchem.8b01979] |
| 47. Yuqing Hou, Wen Zhang, Shengtao Li, Zhen Wang, Huiqing Zhong, Zhiming Liu, Zhouyi Guo. (2018) Investigating the autophagy pathway in silver@gold core–shell nanoparticles-treated cells using surface-enhanced Raman scattering. ANALYST, 143 (15): (3677-3685). [PMID:29975376] [10.1039/C8AN00405F] |
| 48. Xiaoli Gu, Jiaojiao Huang, Lei Zhang, Yu Zhang, Chong-Zhi Wang, Chenghong Sun, Dandan Yao, Fei Li, Lina Chen, Chun-Su Yuan. (2017) Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein-95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies. JOURNAL OF SEPARATION SCIENCE, 40 (17): (3522-3534). [PMID:28704580] [10.1002/jssc.201700595] |
| 49. Cong Luo, Jin Sun, Bingjun Sun, Dan Liu, Lei Miao, Tyler Jay Goodwin, Leaf Huang, Zhonggui He. (2016) Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine. Small, 12 (46): (6353-6362). [PMID:27689847] [10.1002/smll.201601597] |
| 50. Peng Xue, Dan Liu, Jing Wang, Na Zhang, Jiahua Zhou, Lin Li, Weiling Guo, Mengchi Sun, Xiangfei Han, Yongjun Wang. (2016) Redox-Sensitive Citronellol–Cabazitaxel Conjugate: Maintained in Vitro Cytotoxicity and Self-Assembled as Multifunctional Nanomedicine. BIOCONJUGATE CHEMISTRY, [PMID:27070505] [10.1021/acs.bioconjchem.6b00155] |
| 51. Lili Zhao, Shuhua Zhu, Jie Zhou. (2012) A novel amperometric nitric oxide sensor based on imprinted microenvironments for controlling metal coordination. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2012.05.035] |
| 52. Luo Juan, Yu Yao, Wang Ke, He Sizhe, Wang Longjie, Liang Fangfang, Chin Jason W., Tang Shan. (2024) Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification. Nature Protocols, [PMID:38867073] [10.1038/s41596-024-01006-x] |
| 53. Tengfei Xiong, Mingyue Yu, Mei Li, Christopher A. Reilly, Xinghui Qiu. (2024) CYP6B6 mediated adaptation to capsaicinoids in the generalist Helicoverpa armigera and specialist H. assulta: Transcriptional response and metabolic detoxification. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39631573] [10.1016/j.ijbiomac.2024.138286] |
| 54. Shi Haoyu, Song Libiao, Wu Yonghui, Shen Ruonan, Zhang Chenxu, Liao Xingzhi, Wang Qiuhong, Zhu Jie. (2024) Edaravone Alleviates Traumatic Brain Injury by Inhibition of Ferroptosis via FSP1 Pathway. MOLECULAR NEUROBIOLOGY, [PMID:38733490] [10.1007/s12035-024-04216-2] |
| 55. Xue Ran, Ying-jie Wang, Shi-gang Li, Chi-bing Dai. (2024) Effects of Bifidobacterium and rosuvastatin on metabolic-associated fatty liver disease via the gut–liver axis. Lipids in Health and Disease, [PMID:39696288] [10.1186/s12944-024-02391-8] |
| 56. Yaoyao Qi, Shun Zhong, Feng Pan, Junfu Zhou, Zhiyu Wang, Zeyuan Deng, Hongyan Li. (2024) Effects of different wall-breaking methods on the nutrient release of Ganoderma lucidum spore powder during in vitro digestion. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 104 (11): (6657-6666). [PMID:38545871] [10.1002/jsfa.13490] |
| 57. Tang Shuai, Li Jia, Li Yi, Du Haitao, Zhu Wenya, Zhang Ru, Wan Jun. (2024) Effects of Saccharomyces boulardii on microbiota composition and metabolite levels in the small intestine of constipated mice. BMC MICROBIOLOGY, 24 (1): (1-13). [PMID:39578737] [10.1186/s12866-024-03647-0] |
| 58. Chang Liu, Qi Yan, Xuying Ding, Meijun Zhao, Chen Chen, Qian Zheng, Huiying Yang, Yining Xie. (2024) Functional modification of recombinant brain-derived neurotrophic factor and its protective effect against neurotoxicity. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:38621565] [10.1016/j.ijbiomac.2024.131610] |
| 59. Ouyang Zheng, Xiaojie Cao, Yanqing Teng, Qinxiu Sun, Shucheng Liu. (2024) Inactivation effect and kinetics of cathepsin L from white shrimp (Litopenaeus vannamei) by dense phase carbon dioxide. Current Research in Food Science, [PMID:39435452] [10.1016/j.crfs.2024.100873] |
| 60. Liu Hua, Liu Huina, Yang Qiubo, Fan Zhipeng. (2024) LncRNA SNHG1 enhances cartilage regeneration by modulating chondrogenic differentiation and angiogenesis potentials of JBMMSCs via mitochondrial function regulation. Stem Cell Research & Therapy, 15 (1): (1-21). [PMID:38886785] [10.1186/s13287-024-03793-2] |
| 61. Ziang Zhou, Yumeng Wang, Yu Xing, Shuman Pan, Wanru Wang, Jie Yang, Wenyuan Wu, Jie Zhou, Luyi Huang, Qiongdan Liang, Dongmei Zhang, Lingdong Kong. (2024) Magnolol Inhibits High Fructose-Induced Podocyte Inflammation via Downregulation of TKFC/Sp1/HDAC4/Notch1 Activation. Pharmaceuticals, 17 (11): (1416). [PMID:39598328] [10.3390/ph17111416] |
| 62. Ruxia Liu, Changfu Yang, Xin Yang, Jia Yu, Wenchao Tang. (2024) Network toxicology, molecular docking technology, and experimental verification revealed the mechanism of cantharidin-induced testicular injury in mice. TOXICOLOGY AND APPLIED PHARMACOLOGY, [PMID:38582374] [10.1016/j.taap.2024.116921] |
| 63. Kun Wang, Bowei Du, Zhiheng Shi, Guiya Deng, Shangwei Guo, Haoyu Yang, Yaqin Huang. (2025) Selenium chelating collagen peptides as tyrosinase inhibitor: Structure characterization and inhibitory activity. JOURNAL OF FOOD SCIENCE, 90 (3): (e70108). [PMID:40111006] [10.1111/1750-3841.70108] |
| 64. Liu Miao, Xie Wen-jie, Zhang Xu, Wu Wei, Li Guang, Wang Lu. (2025) Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro. MOLECULAR MEDICINE, 31 (1): (1-11). [PMID:39881219] [10.1186/s10020-025-01096-7] |
| 65. Shanbo Ma, Rui Zhang, Long Li, Jin Wang, Meiling Zheng, Xiaodi Guo, Shan Miao, Wei Quan, Wenjuan Liu, Xiaopeng Shi. (2025) Structural characterization of an apple polysaccharide and its anti-inflammatory effect through suppressing TLR4/NF-κB signaling. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39800032] [10.1016/j.ijbiomac.2025.139760] |
| 66. Yujing Du, Linjie Li, Xixuan Li, Jingxuan Tan, Yanjie Qin, Yongning Lv, Xuejia Zhai. (2024) Synergistic effects and molecular mechanisms of DL-3-n-butylphthalide combined with dual antiplatelet therapy in acute ischemic stroke. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:38295546] [10.1016/j.intimp.2024.111592] |
| 67. Xincheng Huang, Jun Zeng, Siyuan Ruan, Zhuolin Lei, Jingyuan Zhang, Hong Cao. (2024) The use of matrine to inhibit osteosarcoma cell proliferation via the regulation of the MAPK/ERK signaling pathway.. Frontiers in Oncology, [PMID:39161382] [10.3389/fonc.2024.1338811] |
| 68. Li Hu, Haiping Liu, Haixiang Ma, Xingyue Zeng, Yongkai Cao, Bing Liu, Huijun Li, Xiaohan Zhang. (2024) TRAF6-mediated ubiquitination of AKT1 in the nucleus occurs in a β-arrestin2-dependent manner upon insulin stimulation. BIOCHEMICAL PHARMACOLOGY, [PMID:38871335] [10.1016/j.bcp.2024.116362] |
| 69. Xia Gao, Meng Gui, Shengjun Chen, Xiao Hu, Juan You, Tao Yin, Yang Hu, Shanbai Xiong, Ru Liu. (2025) Insights into HIU enhancement of salt-reduced surimi gelation properties: Dual regulation of endogenous transglutaminase activation and protease inhibition. ULTRASONICS SONOCHEMISTRY, [PMID:40834706] [10.1016/j.ultsonch.2025.107516] |
| 70. Y. S. Miao, Q. X. Han, K. X. Wang, X. D. Fan, Z. Zhang, L. Chen, D. Z. Zheng, S. Yue, L. Lei, L. Y. Liu, J. C. Li, G. J. Liu. (2025) Indirubin prevents structural damage to chicken lungs and trachea caused by Mycoplasma gallisepticum infection through attenuating oxidative stress and apoptosis. BRITISH POULTRY SCIENCE, [PMID:40757472] [10.1080/00071668.2025.2454965] |
| 71. Liu Nan-nan, Ren Qing-dan, Li Long, Wang Li-na, Shi Guang-liang, Qin Shou-tao. (2025) Multi-omics analysis of the characteristic components of Apis Cerana honey from Changbai mountain. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, [10.1007/s00217-025-04903-x] |
| 72. Xue Yu-Long, Zhang Sheng-Xiao, Zheng Chao-Feng, Li Yu-Feng, Zhang Li-Hui, Hao Yu-Fei, Wang Shu, Li Xue-Wen. (2019) Silencing of STAT4 Protects Against Autoimmune Myocarditis by Regulating Th1/Th2 Immune Response via Inactivation of the NF-κB Pathway in Rats. INFLAMMATION, 42 (4): (1179-1189). [PMID:30848408] [10.1007/s10753-019-00978-3] |
| 73. Bingchu Li, Zhenni Liu, Nijiao Qin, Binghui Li, Zhiyang Chen, Ziyang Li, Xing Lyu, Li Tan, Zhe Guo, Weimin Wu, Zhongyuan Xiang, Zhendong Liu, Qichen Long, Min Hu. (2025) An automated magnetic-bead-assisted liquid chromatography-tandem mass spectrometry method for analyzing angiotensins, ALD, and 18-OH derivatives: application of primary aldosteronism early screening and subtyping. TALANTA, [PMID:40367856] [10.1016/j.talanta.2025.128268] |
| 74. Yue Liu, Wansen Tan, Jingjun Hong. (2025) Co-Expression and Purification of the Complex of Single-Chain H2B-H2A.Z and Histone Chaperone YL1. Current Protocols, 5 (5): (e70151). [PMID:40421937] [10.1002/cpz1.70151] |
| 75. Yiming Zhao, Jingjun Hong. (2025) Purification of Recombinant Histones and Mononucleosome Assembly. Current Protocols, 5 (5): (e70155). [PMID:40402568] [10.1002/cpz1.70155] |
| 76. Yiming Zhao, Jingjun Hong. (2025) Expression, Purification, and ATP Hydrolysis Activity Measurement of CtISWI and CtATPase. Current Protocols, 5 (10): (e70241). [PMID:41133289] [10.1002/cpz1.70241] |
| 77. Jinwei Zhai, Wansen Tan, Lei Ji, Jingjun Hong. (2025) Fermentation and Purification of Recombinant Human Type III Collagen Expressed in Escherichia coli. Current Protocols, 5 (12): (e70284). [PMID:41452303] [10.1002/cpz1.70284] |
| 78. Zhang Mingxiang, Yang Tao, Qian Youcun. (2025) APOL4-mediated intracellular cholesterol trafficking is essential for glioblastoma cell growth. BMC CANCER, 25 (1): (1-16). [PMID:40399861] [10.1186/s12885-025-14316-4] |
| 79. Tonghao Yao, Liangliang Liu, Yibo Miao, Xinxin Li, Ying Yu, Rongyao Sun, Yining Zhang, Luping Cui, Xu Ma. (2025) High-Yield Extruded Nanovesicles From Adipose Stem Cells Promote High-Quality Healing of Diabetic Wound Through WNT/β-Catenin Pathway Activation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 29 (19): (e70877). [PMID:41058030] [10.1111/jcmm.70877] |
| 80. Hao Li, Xiaowei Xie, Yu Zhang, Xiaopeng Han, Ting Shi, Jiayin Li, Wanyu Chen, Qin Wei, Hong Pan, Shuxian Xu, Qiuyu Chen, Lifang Yin, Chao Qin. (2025) MOF-Engineered Platelet-Mimicking Nanocarrier-Encapsulated Cascade Enzymes for ROS Scavenging and Anti-Inflammation in Cerebral Ischemia–Reperfusion Injury. Pharmaceutics, 17 (11): (1478). [PMID:41304816] [10.3390/pharmaceutics17111478] |
| 81. Yingzhi Yang, Ziyan Wan, Luyi Huang, Ziang Zhou, Wanru Wang, Yu Xing, Shijie Li, Yufan Du, Jiufang Huang, Yanqing Wu, Mengyu Fan, Jiahuang Li, Lingdong Kong, Dongmei Zhang. (2025) Morin Alleviates Fructose-Driven Disturbance of Podocyte Mitochondrial Energy Metabolism by Inhibiting Adenosine 5′-Monophosphate Deaminase Activity to Improve Glomerular Injury. Pharmaceuticals, 18 (12): (1883). [PMID:41471373] [10.3390/ph18121883] |
| 82. Lu Tian, Baiqiang Chen, Jingxue Huang, Yu Cao, Tingting Wu. (2026) A multifunctional biomimetic interface biosensor for one-step amplified detection of tumor-derived exosomal miRNA. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2026.173463] |
| 83. Yu Lei, Xiaopeng Yan, Shengwen Zhao, Qian Zhang, Luo Liu, Qian Sun. (2026) Exploring a green-approach for 6PPD and 6PPD-Q removal: Riverine plants in natural wetlands. JOURNAL OF HAZARDOUS MATERIALS, [PMID:41713261] [10.1016/j.jhazmat.2026.141511] |
| 84. Lin Gui, Chunying Chen, Jing Gao, Mengying Zhu, Zhuo Xu, Hu Zhou, Naixia Zhang, Li Shi. (2026) Gossypol suppresses tumorigenesis through inhibition of multiple deubiquitinating enzymes. BIOORGANIC CHEMISTRY, [PMID:41855638] [10.1016/j.bioorg.2026.109763] |
| 85. Weiping Mo, Zhuo Liu, Xiaoyang Zhang, Shulei Li, Anguo Huo, Yiwen Gao, Qiujiao Yang, Zhuangzhi Zhou, Liping Yu, Lei Li. (2026) Calmodulin-like protein condensates decode PAMP-induced nuclear calcium to activate plant immunity. Cell Reports, 45 (4): [PMID:41849347] [10.1016/j.celrep.2026.117092] |
| 86. Chunlei Li, Yanxiao Xiang, Tao Jiang, Jiyuan Zhang, Xuekui Xia, Anchang Liu. (2026) Screening and characterization of a novel cupin-like polypeptide from Oyster (Ostrea gigas) and its anti-inflammatory effect via TAK1 mediated NF-κB pathway. Food Chemistry-X, [PMID:42078028] [10.1016/j.fochx.2026.103884] |
| 87. De Dong, Huiling Li, Yuwei Zhu, Zebin Lu, Junliang Zhu, Xinyu Tian, Zhiwei Huang. (2026) Butyrophilin-like 3 and 8 tetramers clamp Vγ4Vδ1 T cell receptors for antigen-independent activation. IMMUNITY, [PMID:42546693] [10.1016/j.immuni.2026.07.004] |
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