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L-丝氨酸

弱内源性甘氨酸受体激动剂
189篇引用文献
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Anti-infection (2825) Bacterial (718) 化学生物学 (1259) 肽化学 (313)
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基本描述

别名 L-蚕丝氨基酸 | (S)-2-氨基-3-羟基丙酸 | L-2-氨基-3-羟基丙酸 | L-β-羟基丙氨酸
英文别名 Ser | 4-04-00-03118 (Beilstein Handbook Reference) | beta-Hydroxy-L-alanine | bmse000048 | MFCD00064224 | SERINE [EP MONOGRAPH] | STR02557 | H-Ser | L-2-Amino-3-hydroxypropionic acid | Serina [Spanish] | SERINE [INN] | 2-Amino-3-hydroxypropionic acid | 3-
规格或纯度 Moligand™, ≥99%
英文名称 L-Serine
生化机理 抑制性甘氨酸受体的内源性激动剂。
储存温度 干燥
运输条件 常规运输
产品介绍

有甜味。溶于水和无机酸，不溶于有机溶剂、无水乙醇、乙醚和苯。 生化研究。配制组织培养基。

AI解读

关联靶点（人）

GPRC6A Tchem G 蛋白偶联受体家族 C 组 6 成员 A(G-protein coupled receptor family C group 6 member A) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC1A4 Tbio Neutral amino acid transporter A (18 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC1A5 Tchem Neutral amino acid transporter B(0) (65 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Pkm Pyruvate kinase isozymes M1/M2 (66 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ggt1 Gamma-glutamyltranspeptidase 1 (36 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc16a10 Monocarboxylate transporter 10 (73 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gamma-glutamyltranspeptidase (21 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAP1 General amino-acid permease GAP1 (481 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc1a5 Amino acid transporter (271 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc7a10 Asc-type amino acid transporter 1 (14 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488179970
EC号 200-274-3
分子类型 小分子
IUPAC Name (2S)-2-amino-3-hydroxypropanoic acid
INCHI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChi Key MTCFGRXMJLQNBG-REOHCLBHSA-N
Canonical SMILES C(C(C(=O)O)N)O
Isomeric SMILES C([C@@H](C(=O)O)N)O
WGK Germany 1
RTECS VT8100000
PubChem CID 5951
分子量 105.09
Beilstein号 1721404
Reaxy-Rn 1721404

化学和物理性质

溶解性 Soluble in water. Insoluble in ethanol, ether and benzene
密度 1.6
比旋光度 15° (C=10,HCl(1+5))
熔点 228°C(dec.)(lit.)
分子量 105.090 g/mol
XLogP3 -3.100
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 105.043 Da
单同位素质量Monoisotopic Mass 105.043 Da
拓扑极表面积Topological Polar Surface Area 83.600 Ų
重原子数Heavy Atom Count 7
形式电荷Formal Charge 0
复杂度Complexity 72.600
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 1
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 1
RTECS VT8100000
Reaxy-Rn 1721404
Merck Index 8460
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 日期 货号
D2510036 分析证书 25-02-07 S103483
A2517482 分析证书 25-02-07 S103483
A2517483 分析证书 25-02-07 S103483
A2517484 分析证书 25-02-07 S103483
A2517485 分析证书 25-02-07 S103483
A2517486 分析证书 25-02-07 S103483
J2431470 分析证书 24-11-08 S103483
J2431469 分析证书 24-11-08 S103483
J2431468 分析证书 24-11-08 S103483
J2431467 分析证书 24-11-08 S103483
J2431466 分析证书 24-11-08 S103483
I2404244 分析证书 24-06-29 S103483
F2421518 分析证书 24-06-29 S103483
F2421519 分析证书 24-06-29 S103483
F2421520 分析证书 24-06-29 S103483
E2423583 分析证书 24-03-13 S103483
E2423580 分析证书 24-03-13 S103483
E2410191 分析证书 24-03-13 S103483
B2422159 分析证书 24-02-29 S103483
B2422158 分析证书 24-02-29 S103483
B2422150 分析证书 24-02-29 S103483
B2422149 分析证书 24-02-29 S103483
B2422148 分析证书 24-02-29 S103483
L2308044 分析证书 23-12-19 S103483
H2331275 分析证书 23-09-08 S103483
H2331267 分析证书 23-09-08 S103483
H2331257 分析证书 23-09-08 S103483
H2331245 分析证书 23-09-08 S103483
H2331241 分析证书 23-09-08 S103483
F23131265 分析证书 23-06-14 S103483
F23131268 分析证书 23-06-14 S103483
F23131267 分析证书 23-06-14 S103483
F23131266 分析证书 23-06-14 S103483
F23131264 分析证书 23-06-14 S103483
A2310205 分析证书 23-01-16 S103483
A2310214 分析证书 23-01-16 S103483
A2310224 分析证书 23-01-16 S103483
A2310230 分析证书 23-01-16 S103483
A2310231 分析证书 23-01-16 S103483
A2310239 分析证书 23-01-16 S103483
D2328039 分析证书 23-01-16 S103483
G2230165 分析证书 22-08-06 S103483
G2230163 分析证书 22-08-05 S103483
G2230333 分析证书 22-08-05 S103483
G2230167 分析证书 22-08-05 S103483
G2230166 分析证书 22-08-05 S103483
E1809101 分析证书 22-03-31 S103483

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