计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温。 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 78 篇同行评审文献引用。
概述
应用
Valuable reagent offered as a solution in dichloromethane for more convenient handling. Alternative to dicyclohexylcarbodiimide in peptide synthesis. Coupling reagent for peptide syntheses. DIC ( N , N′ -Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N -allylglycine to form N -allylpeptide.
General Description
DIC is an abbreviated form of N , N ′-diisopropylcarbodiimide. It plays a role in the cyclization of N -(β-hydroxy)amides to form 2-oxazolines.
Application
Valuable reagent offered as a solution in dichloromethane for more convenient handling. Alternative to dicyclohexylcarbodiimide in peptide synthesis. Coupling reagent for peptide syntheses. DIC ( N , N′ -Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N -allylglycine to form N -allylpeptide.
规格
英文别名
EINECS 211-743-7 | diisopropyl carbodiimide | N,N'-Diisopropyl carbodimide | dipropan-2-ylmethanediimine | N-((isopropylimino)methyl-ene)propan-2-amine | N-((isopropylimino)methylene)propan-2-amine | STR04127 | UNII-OQO20I6TWH | DIC, 99% | MFCD00065689 |
规格或纯度
1 M in dichloromethane
英文名称
Diisopropylcarbodiimide solution
储存条件
室温
名称和识别符
EC号
211-743-7
分子类型
小分子
INCHI
1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
InChi Key
BDNKZNFMNDZQMI-UHFFFAOYSA-N
Smiles
CC(C)N=C=NC(C)C
Isomeric SMILES
CC(C)N=C=NC(C)C
UN Number
分子量
126.20
Beilstein号
878281
Reaxy-Rn
878281
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=878281&ln=
技术文档
高级数据
三维结构
交互式化学结构模型
关联靶点（人）
KCNH2
Tclin
HERG
(29587 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
密度
1.2231
折光率
1.433
闪点(℉)
91°F
闪点(℃)
31°C
沸点
145-148°C
分子量
126.200 g/mol
XLogP3
2.600
氢键供体数Hydrogen Bond Donor Count
0
氢键受体数Hydrogen Bond Acceptor Count
2
可旋转键计数Rotatable Bond Count
2
精确质量Exact Mass
126.116 Da
单同位素质量Monoisotopic Mass
126.116 Da
拓扑极表面积Topological Polar Surface Area
24.700 Ų
重原子数Heavy Atom Count
9
形式电荷Formal Charge
0
复杂度Complexity
101.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
信号词
危险
危险声明
H226: 易燃液体和蒸气
H315: 引起皮肤刺激
H317: 可能引起皮肤过敏反应
H318: 造成严重的眼睛损伤
H331: 吸入会中毒
H334: 吸入可能引起过敏或哮喘病症状或呼吸困难
H336: 可能引起嗜睡或头晕
H351: 怀疑引起遗传缺陷
预防措施声明
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。
P233: 保持容器密闭。
P240: 地面/粘结容器和接收设备
P241: 使用防爆的[电气/通风/照明/.../]设备。
P242: 仅使用无火花的工具。
P243: 采取防静电措施
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P271: 仅在室外或通风良好的地方使用。
P272: 被污染的工作服不允许离开工作场所
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P284: 如果通风不良，请佩戴呼吸防护装置。
P320: 迫切需要特殊治疗（请参阅此标签上的...）。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P403+P235: 存放在通风良好的地方。保持低温。
P501: 将内容物/容器处理到。。。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。
P317: 寻求紧急医疗救助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P316: 立即寻求紧急医疗救助。
P319: 如果你感到不适，请寻求医疗帮助。
P342+P316: 如果出现呼吸道症状：立即寻求急救。
WGK Germany
3
RTECS
FF2175000
个人防护装备
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
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目录： 技术文章
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目录： 技术文章
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目录： 技术文章
New Progress in the Solid-Phase Synthesis of Sterically Hindered Peptides: Background, Core Breakthroughs, and Implications for Automation Compatibility of the RMMR Strategy
目录： 技术文章
TCFH–NMI Amidation in Highly Aqueous Media: Research Value, Methodological Understanding, and Experimental Insights
目录： 技术文章
A New Balance in Coupling Reagents: How DMT-TU Balances Reactivity, Racemization Control, and Thermal Hazard
目录： 技术文章
The Positioning of TBTU in Practice: Racemization Risk, Extended Uses, and Selection Criteria
目录： 技术文章
From “High Yield” to “Configuration Retention”: Activation-Stage Risks, Route Differences, and Selection Principles for Coupling Systems
目录： 技术文章
The Methodological Value of HATU in Difficult Couplings: Reactivity Advantages, Stereochemical Retention, and Condition Management
目录： 技术文章
The Methodological Value of Boc-Oxyma: Low-Racemization Coupling, Route Continuity, and Extended Applications
目录： 技术文章
Low Racemization in Peptide Synthesis Is Not Just About Reagent Choice: Stereochemical Risk During the Activation Stage and Practical Strategies for Experimental Control
目录： 技术文章
The Methodological Value of TCFH: Advantages in Challenging Amidation and the Switching Logic of Carboxylic Acid Activation Pathways
目录： 技术文章
Ynamide Coupling Reagents: From Low-Epimerization Activation Pathways to More Practically Usable N→C Inverse Peptide Synthesis
目录： 技术文章
Decision Logic for Peptide Synthesis Routes: Applicability and Criteria for Choosing among SPPS, LPPS, and Recombinant Expression
目录： 技术文章
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目录： 技术文章
DMAP Is More Than Just an Organic Base: Experimental Judgment from Nucleophilic Acyl Transfer to Esterification and Macrolactonization
目录： 技术文章
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目录： 技术文章
Experimental Selection Logic for Pentafluorophenyl-Based Systems: Practical Judgment from Active Esters and Pre-Activated Monomers to Downstream Transformations
目录： 技术文章
Experimental Judgment in Oxyma Coupling Systems: Coupling Efficiency, Racemization Control, and the HCN Risk in DIC-Based Systems
目录： 技术文章
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目录： 技术文章
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目录： 技术文章
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目录： 技术文章
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目录： 技术文章
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目录： 技术文章
Logic for Selecting Amidation Reagents in Aqueous Media: Competing Reactions, Activated Intermediates, and Substrate Effects
目录： 技术文章
Where Does the Selectivity in Piperidine C–H Functionalization Come From? — Nitrogen Effects, Chair Conformations, and Four Classes of Key Intermediates
目录： 技术文章
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目录： 技术文章
此产品的引用文献
溶液计算器
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