计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 85 篇同行评审文献引用。
概述
Nicotinamide is a NAD+ and NADP+ coenzyme precursor. Nicotinamide is an antiinflammatory agent and a PARP-1 enzyme inhibitor.生化研究，配制组织培养基。
Information
Nicotinamide (NSC 13128) Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins .
In vitro
Nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of a sir2 mutant. Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. Nicotinamide results in a twofold increase in DNA content and a threefold increase in insulin content in the fetal cells. Nicotinamide induces differentiation and maturation of human fetal pancreatic islet cells. Nicotinamide regulates sirtuins by switching between deacetylation and base exchange. Nicotinamide switching is quantitated for the Sir2s from Archeaglobus fulgidus (Sir2Af2), Saccharomyces cerevisiae (Sir2p), and mouse (Sir2alpha). Nicotinamide selectively reduces a specific phospho-species of tau (Thr231) that is associated with microtubule depolymerization in Alzheimer\'s disease transgenic mice, in a manner similar to inhibition of SirT1. Nicotinamide also dramatically increases acetylated alpha-tubulin, a primary substrate of SirT2, and MAP2c in Alzheimer\'s disease transgenic mice, both of which are linked to increased microtubule stability. Nicotinamide fosters DNA integrity and maintains phosphatidylserine membrane asymmetry to prevent cellular inflammation, cellular phagocytosis and vascular thrombosis. Nicotinamide both prevents and reverses neuronal and vascular cell injury.
In vivo
In the mouse, nicotinamide given i.p. at doses of 100-500 mg/kg showed biphasic elimination with dose-dependent changes in half-life. The initial half-life increased significantly (P <0.05) from 0.8 to 2 h and the terminal half-life increased from 3.4 to 5.6 h over the dose range studied. Clearance, however, decreased significantly from 0.3 to 0.24 L/kg/h only at the highest dose. Peak concentrations increased in a dose-dependent manner from 1,000 to 4,800 nmol/ml. The bioavailability given via the i.p. as compared with the i. v. route was close to 100%.
Cell Data
cell lines：
Concentrations：33 μM
Incubation Time：7 days and 14 days
Powder Purity:≥99%
规格
英文别名
Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452 | 3-Pyridinecarboxamide
规格或纯度
10mM in DMSO
英文名称
Nicotinamide (NSC 13128)
生化机理
烟酰胺（NSC 13128，烟酰胺，维生素 PP，烟酸酰胺，维生素 B3，NSC 27452）是一种水溶性维生素，是辅酶 NAD 和 NADP 的活性成分，也是 sirtuins 的抑制剂。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
202-713-4
分子类型
小分子
Isomeric SMILES
C1=CC(=CN=C1)C(=O)N
分子量
122.12
Beilstein号
383619
Reaxy-Rn
383619
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=383619&ln=
技术文档
高级数据
化学和物理性质
闪点(℉)
302 °F
闪点(℃)
150 °C
熔点
128-131°C
安全和危险性（GHS）
WGK Germany
1
RTECS
QS3675000
Merck Index
6523
个人防护装备
dust mask type N95 (US),Eyeshields,Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 C2307019 |
分析证书 | N407906 |
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此产品的引用文献
溶液计算器
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