计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
有货
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 45 篇同行评审文献引用。
概述
氯喹是喹诺酮家族的一员，是一种弱的嵌入剂。氯喹用于治疗阿米巴病、类风湿性关节炎、盘状和系统性红斑狼疮。DNA嵌入剂。还可用于提高转染效率。 氯喹二磷酸盐已用于： · 体外抗疟原虫试验 · 转染及感染试验 · 自噬抑制 · 诱导多能干细胞（iPS）分化成心肌细胞 · 感染血液的流动治疗
Chloroquine Phosphate is an antimalarial agent that has been discovered to have a distinct affinity for melanin. Used in the treatment of arthritis, malaria and Lupus. Chloroquine Phosphate is a substrate of MRP.
An antimalarial compound
规格
别名
磷酸氯喹 | N4-(7-氯喹啉-4-基)-N1,N1-二乙基戊烷-1,4-二胺二磷酸 | N4-(7-氯-4-喹啉基)-N1,N1-二甲基-1,4-戊二胺 二磷酸盐 | 氯喹 二磷酸盐 | 氯喹二磷酸盐 | 7-氯-4-[4-(二乙氨基)-1-甲基丁氨基]喹啉二磷酸盐 | N4-(7-氯-4-喹啉基)-N1,N1-二乙基-1,4-戊二胺二磷酸盐
英文别名
1,4-Pentanediamine, N(sup 4)-(7-chloro-4-quinolinyl)-N(sup 1),N(sup 1)-diethyl-, phosphate (1:2) | CHLOROQUINE DIPHOSPHATE [MI] | NCGC00093746-02 | Aralen phosphate | CHLOROQUINE PHOSPHATE (MART.) | HMS2096N17 | UNII-6E17K3343P | CHLOROQUINE PHOSPHATE (US
规格或纯度
≥99%
英文名称
Chloroquine Phosphate
生化机理
标准的抗疟疾药物。在多药耐药细胞系中用作MRP的底物并通过基于喹啉的光活性药物IAAQ（N-[4-[1-羟基-2-（二丁基氨基）乙基]喹啉-8-基] -4-叠氮基水杨酰胺）抑制MRP的光亲和标记。抗疟剂。抑制肿瘤细胞的生长和转移，并诱导细胞凋亡。与Fe（II）-原卟啉IX（FP）结合形成FP-氯喹复合物，导致细胞裂解和寄生虫细胞自消化。
应用
DNA嵌入剂。还可用于提高转染效率。
氯喹二磷酸盐已用于：
· 体外抗疟原虫试验
· 转染及感染试验
· 自噬抑制
· 诱导多能干细胞（iPS）分化成心肌细胞
· 感染血液的流动治疗
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
作用机制
铁原卟啉 IX 抑制剂
备注
如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
纯度
≥99%
名称和识别符
PubChem SID
EC号
200-055-2
分子类型
小分子
IUPAC Name
4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
INCHI
1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChi Key
QKICWELGRMTQCR-UHFFFAOYSA-N
Smiles
CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
Isomeric SMILES
CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
PubChem CID
分子量
515.86
Beilstein号
4223142
Reaxy-Rn
4223142
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机杂环化合物 |
| 类（Class) | 喹啉及其衍生物 |
| 亚类（Subclass） | 氨基喹啉及其衍生物 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 4-氨基喹啉 |
| 其他上位类（Alternative Parents） | 氯喹啉类 仲烷基芳胺 氨基吡啶及其衍生物 有机磷酸及其衍生物 苯类化合物 芳基氯化物 杂芳族化合物 三烷基胺 氮杂环化合物 有机光子化合物 有机氯化物 有机氧化物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 芳香族杂多环化合物 |
| 取代基（Substituents） | 4-氨基喹啉 - 氨基酸 - 氨基吡啶 - 芳香族杂多环化合物 - 芳基氯化物 - 芳基卤化物 - 氮杂环 - 苯基化合物 - 氯喹啉 - 卤喹啉 - 杂芳香族化合物 - 烃衍生物 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机磷酸酯 - 有机氯化物 - 有机卤化物 - 有机氮化合物 - 有机氮化合物 - 吡啶 - 二级脂肪族/芳香族胺 - 醛基 - 三元脂肪胺 - 三芳基胺 |
| 描述（Description） | 该化合物属于有机化合物类别中的4-氨基喹啉类。这类化合物在喹啉环系的4位带有氨基。 |
| 外部描述符（External Descriptors） | 暂无 |
三维结构
交互式化学结构模型
关联靶点（人）
KCNH2
Tclin
HERG
(29587 活性数据)
CYP2D6
Tclin
Cytochrome P450 2D6
(33882 活性数据)
CYP3A4
Tclin
Cytochrome P450 3A4
(53859 活性数据)
K562
(73714 活性数据)
MCF7
(126967 活性数据)
MDA-MB-468
(9477 活性数据)
MRC5
(9203 活性数据)
Cell line
(371 活性数据)
HepG2
(196354 活性数据)
NCI-H460
(60772 活性数据)
KB
(17409 活性数据)
HeLa
(62764 活性数据)
MDA-MB-231
(73002 活性数据)
HSD17B10
Tchem
Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
(20669 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
APEX1
Tchem
DNA-(apurinic or apyrimidinic site) lyase
(38016 活性数据)
TDP1
Tchem
Tyrosyl-DNA phosphodiesterase 1
(345557 活性数据)
KDM4E
Tchem
Lysine-specific demethylase 4D-like
(40243 活性数据)
SLCO1B1
Tchem
Solute carrier organic anion transporter family member 1B1
(2672 活性数据)
SLCO1B3
Tchem
Solute carrier organic anion transporter family member 1B3
(2517 活性数据)
DNA
(187 活性数据)
184B5
(172 活性数据)
关联靶点（其它种属）
Histidine-rich protein (528 活性数据)
Galc
Galactocerebrosidase (11 活性数据)
Trypanosoma brucei brucei (13300 活性数据)
Entamoeba histolytica (2676 活性数据)
Plasmodium falciparum (966862 活性数据)
Plasmodium berghei (192651 活性数据)
Plasmodium yoelii (6656 活性数据)
Mus musculus (284745 活性数据)
CHO (4503 活性数据)
Vero (26788 活性数据)
MAC15A (81 活性数据)
Calf thymus DNA (4845 活性数据)
Ferriprotoporphyrin IX (165 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
botA
Botulinum neurotoxin type A (1303 活性数据)
Mapt
Microtubule-associated protein tau (6 活性数据)
nfo
Endonuclease 4 (425 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
DMSO <1 mg/mL Water 100 mg/mL Ethanol <1 mg/mL
敏感性
对光敏感
熔点
199°C
分子量
515.900 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count
7
氢键受体数Hydrogen Bond Acceptor Count
11
可旋转键计数Rotatable Bond Count
8
精确质量Exact Mass
515.135 Da
单同位素质量Monoisotopic Mass
515.135 Da
拓扑极表面积Topological Polar Surface Area
184.000 Ų
重原子数Heavy Atom Count
32
形式电荷Formal Charge
0
复杂度Complexity
358.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
1
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
3
安全和危险性（GHS）
信号词
危险
危险声明
H302: 吞食有害
H360: 可能损害生育力或未出生的孩子
H373: 通过长时间或反复暴露对器官造成损害
预防措施声明
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P330: 漱口
P405: 密闭存放
P501: 将内容物/容器处理到。。。
P203: 使用前，获取、阅读并遵守所有安全说明。
P301+P317: 如果被吞咽：请寻求医疗帮助。
P318: 如果暴露或担心，请就医。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
RTECS
VB2450000
Merck Index
2163
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
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分析证书 | C129284 |
| F2624159 |
分析证书 | C129284 |
| D2616054 |
分析证书 | C129284 |
| I2510116 |
分析证书 | C129284 |
| B2223658 |
分析证书 | C129284 |
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分析证书 | C129284 |
| E2015085 |
分析证书 | C129284 |
| D2525071 |
分析证书 | C129284 |
| G2508093 |
分析证书 | C129284 |
| D2515071 |
分析证书 | C129284 |
| D2518080 |
分析证书 | C129284 |
| F2417079 |
分析证书 | C129284 |
| C2414241 |
分析证书 | C129284 |
| C2414240 |
分析证书 | C129284 |
| C2414239 |
分析证书 | C129284 |
| A2418058 |
分析证书 | C129284 |
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分析证书 | C129284 |
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分析证书 | C129284 |
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分析证书 | C129284 |
| B2223776 |
分析证书 | C129284 |
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此产品的引用文献
引用文献
| 1. Shengchao Hu, Jian Zhao, Shangbiao Fang, Kehui Guo, Weixiao Qi, Huijuan Liu. (2023) Neurotoxic effects of chloroquine and its main transformation product formed after chlorination. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:37898196] [10.1016/j.scitotenv.2023.168043] |
| 2. Liu Jin, Chen Yuqian, Chen Huan, Wang Yan, Li Danyang, Zhang Qianqian, Chai Limin, Qiu Yuanjie, Zhang Jia, Shen Nirui, Wang Qingting, Wang Jian, Li Manxiang. (2023) Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation. RESPIRATORY RESEARCH, 24 (1): (1-14). [PMID:37674165] [10.1186/s12931-023-02526-y] |
| 3. Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai. (2023) Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation. MATERIALS & DESIGN, [10.1016/j.matdes.2023.112212] |
| 4. Qiang Yang, Longgang Chu, Tongliang Wu, Yiyi Zhou, Cun Liu, Long Cang, Guodong Fang, Peixin Cui, Yujun Wang. (2023) Investigation of dual-functional carbon cathode catalysts from agricultural wastes in the heterogeneous electro-Fenton process. APPLIED CATALYSIS B-ENVIRONMENTAL, [10.1016/j.apcatb.2023.123018] |
| 5. Shengchao Hu, Shangbiao Fang, Jian Zhao, Guowei Wang, Weixiao Qi, Gong Zhang, Cunrui Huang, Jiuhui Qu, Huijuan Liu. (2023) Toxicity Evaluation and Effect-Based Identification of Chlorine Disinfection Products of the Anti-COVID-19 Drug Chloroquine Phosphate. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:37188658] [10.1021/acs.est.2c08260] |
| 6. Hongwei Sun, Jinjin He, Yucan Liu, Xianguo Ji, Gang Wang, Xiaoyong Yang, Yanxiang Zhang. (2023) Removal Performance and Mechanism of Emerging Pollutant Chloroquine Phosphate from Water by Iron and Magnesium Co-Modified Rape Straw Biochar. MOLECULES, 28 (8): (3290). [PMID:37110522] [10.3390/molecules28083290] |
| 7. Jinchao Xing, Chen Hu, Siqi Che, Yixin Lan, Lihong Huang, Lele Liu, Youqin Yin, Huanan Li, Ming Liao, Wenbao Qi. (2023) USP1-Associated Factor 1 Modulates Japanese Encephalitis Virus Replication by Governing Autophagy and Interferon-Stimulated Genes. Microbiology Spectrum, 11 (3): [PMID:36988464] [10.1128/spectrum.03186-22] |
| 8. Xueli Hu, Yuanhang Zhou, Yingying Zhou, Yun Bai, Ruiting Chang, Peng Lu, Zhi Zhang. (2022) Insight into core -shell microporous zinc silicate adsorbent to eliminate antibiotics in aquatic environment under the COVID-19 pandemic. Journal of Cleaner Production, [PMID:36504484] [10.1016/j.jclepro.2022.135416] |
| 9. Wang Junqi, Jing Xian, Hua Lizhong, Zheng Yuling, Hu Shiheng, Xiao Jing, Guo Dawei, Wu Wenda, Ji Hui, Peng Lin, Jiang Shanxiang, Gao Xiuge. (2022) Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model. Frontiers in Pharmacology, [PMID:36532753] [10.3389/fphar.2022.1051694] |
| 10. Xinqi Zheng, Pengran Guo, Yue Zhang, Jingwei Xu, Jian Sun, Yongqian Lei. (2022) An ultra sensitive and rapid SERS detection method based on vortex aggregation enhancement effect for anti-infective drug residues detection in water. ANALYTICA CHIMICA ACTA, [PMID:36368827] [10.1016/j.aca.2022.340539] |
| 11. Qinying Liu, Yi Yang, Miaomiao Cheng, Fangting Cheng, Shanshan Chen, Qiuhong Zheng, Yang Sun, Li Chen. (2022) The marine natural product, dicitrinone B, induces apoptosis through autophagy blockade in breast cancer. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 50 (4): (1-13). [PMID:36052845] [10.3892/ijmm.2022.5186] |
| 12. Mengxue Yang, Ruixian Wu, Shengshuai Cao, Yanwei Li, Sisi Huo, Wei Wang, Zhen Hu, Xing Xu. (2022) Versatile pathways for oxidating organics via peroxymonosulfate activation by different single atom catalysts confining with Fe–N4 or Cu–N4 sites. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2022.138606] |
| 13. Zhang Zuo-yan, Dong Shu-min, Liu Ye-han, Zhang Man-man, Zhang Jian-kang, Zhu Hua-jian, Shao Jia-an, Liu Hua-qing, Li Yang-ling, Zhang Chong, Zeng Ling-hui. (2021) Enhanced anticancer activity by the combination of vinpocetine and sorafenib via PI3K/AKT/GSK-3β signaling axis in hepatocellular carcinoma cells. ANTI-CANCER DRUGS, 32 (7): (727). [PMID:33735117] [10.1097/CAD.0000000000001056] |
| 14. Cui Zhai, Wei Feng, Wenhua Shi, Jian Wang, Qianqian Zhang, Xin Yan, Qingting Wang, Shaojun Li, Lu Liu, Yilin Pan, Yanting Zhu, Limin Chai, Cong Li, Pengtao Liu, Yuqian Chen, Manxiang Li. (2020) Sphingosine-1-phosphate promotes pulmonary artery smooth muscle cells proliferation by stimulating autophagy-mediated E-cadherin/CDH1 down-regulation. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:32659302] [10.1016/j.ejphar.2020.173302] |
| 15. Tong Chen, Dong Cen, Zhaohui Ren, Yifan Wang, Xiujun Cai, Jie Huang, Lucy Di Silvio, Xiang Li, Gaorong Han. (2019) Bismuth embedded silica nanoparticles loaded with autophagy suppressant to promote photothermal therapy. BIOMATERIALS, [PMID:31421315] [10.1016/j.biomaterials.2019.119419] |
| 16. Yan Ma, Huajian Chen, Baimei Hao, Junhong Zhou, Gang He, Zhaohua Miao, Yan Xu, Li Gao, Wei Zhou, Zhengbao Zha. (2018) A chloroquine-loaded Prussian blue platform with controllable autophagy inhibition for enhanced photothermal therapy. Journal of Materials Chemistry B, 6 (37): (5854-5859). [PMID:32254706] [10.1039/C8TB01987H] |
| 17. Kaida Kuang, Ya Li, Yang Chen, Yu Ji, Nengqin Jia. (2024) A simplified molecularly imprinted ECL sensor based on Mn2SnO4 nanocubes for sensitive detection of ribavirin. ANALYST, 149 (4): (1318-1326). [PMID:38251970] [10.1039/D3AN02077K] |
| 18. Wentao Lin, Yong Xia, Anqi He, Shuang Chen, Jie Zhang. (2024) Antipsychotic Zuclopenthixol Inhibits Melanoma Growth and Brain Metastasis by Inducing Apoptosis and Cell Cycle Arrest. Frontiers in Bioscience-Landmark, 29 (4): (132). [PMID:38682202] [10.31083/j.fbl2904132] |
| 19. Huang Yeqiong, Song Zhi, Liu Boxia, Zhang Xiayan, Liu Jialu, Li Cheng, Han Dongxu, Xing Chuhan. (2024) Highly Active Co is Injected into the PrSmMnO3 Parent Structure to Promote the 1O2 Pathway to Efficiently Degrade Residual Chloroquine Phosphate in Wastewater. CATALYSIS LETTERS, 155 (1): (1-16). [10.1007/s10562-024-04844-2] |
| 20. Le-le Liu, You-qin Yin, Kai-xiong Ma, Jin-chao Xing, Xing-xing Ren, Jin-yu Huang, Ming Liao, Wen-bao Qi, Li-hong Huang. (2024) Identification critical host factors for Japanese encephalitis virus replication via CRISPR screening of human sgRNA library. VETERINARY MICROBIOLOGY, [PMID:38677125] [10.1016/j.vetmic.2024.110099] |
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常见问题
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本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 50-63-5，分子式为 C18H26ClN3·2H3PO4，分子量为 515.86 g/mol。InChIKey QKICWELGRMTQCR-UHFFFAOYSA-N。
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