K2230658计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
提供 ≥95% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,充氩。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 33 篇同行评审文献引用。
概述
Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type (v-type) H+ ATPase) and belongs to a class of membrane ATPase inhibitors. The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase
Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type (v-type) H+ ATPase) and belongs to a class of membrane ATPase inhibitors. The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.
A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase
规格
英文别名
MFCD06795130 | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-o
规格或纯度
≥95%
英文名称
Bafilomycin A1
生化机理
动物细胞、植物细胞和微生物液泡型H+-ATP酶（V-ATP酶）的特异性抑制剂。高效，选择性液泡（V）-ATPase抑制剂（嗜铬粒细胞颗粒膜中IC 50 = 500 pM）。诱导液泡脱酸并促进细胞凋亡。
储存条件
-20°C储存,充氩
运输条件
超低温运输
作用类型
抑制剂
备注
本产品以一种（或多种）包装尺寸提供，并进行冷冻干燥。因此，内含物可能会覆盖小瓶的底部或壁，因此可能不容易看到。请参阅我们的常见问题解答和信息页面以获取有关处理的更多详细信息。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
纯度
≥95%
名称和识别符
PubChem SID
EC号
621-324-4
分子类型
小分子
IUPAC Name
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
INCHI
1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChi Key
XDHNQDDQEHDUTM-JQWOJBOSSA-N
Smiles
CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C
Isomeric SMILES
C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
分子量
622.83
Beilstein号
4730700
Reaxy-Rn
28187964
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28187964&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
-
界（kingdom)
有机化合物
-
超类（Superclass)
苯丙素类和聚酮类
- 类（Class) 大环内酯类及其类似物
-
超类（Superclass)
苯丙素类和聚酮类
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 苯丙素类和聚酮类 |
| 类（Class) | 大环内酯类及其类似物 |
| 亚类（Subclass） | 暂无 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 大环内酯类及其类似物 |
| 其他上位类（Alternative Parents） | 氧烷 烯酸酯类 仲醇 内酯 半缩醛 氧环化合物 一元羧酸及其衍生物 二烷基醚 有机氧化物 碳氢化合物衍生物 羰基化合物 |
| 分子骨架（Molecular Framework) | 脂肪族杂单环化合物 |
| 取代基（Substituents） | 羟基苯甲酸酯 - 脂肪族杂单环化合物 - α,β-不饱和羧酸酯 - 羰基 - 羧酸衍生物 - 羧酸酰胺 - 二烷基醚 - 乙酰基 - 乙醚 - 半缩醛 - 烃衍生物 - L-α-氨基酸 - 大环内酯 - 单羧酸或其衍生物 - 有机氧化物 - 有机氧化合物 - 有机杂环化合物 - 有机氧化合物 - 氧杂环 - 氧杂环丁烷 - 醛基 |
| 描述（Description） | 该化合物属于大环内酯类及其类似物有机化合物。这类化合物含有至少十二个成员的内酯环。 |
| 外部描述符（External Descriptors） | macrolide antibiotic - cyclic hemiketal - oxanes |
三维结构
交互式化学结构模型
关联靶点（人）
ATP6AP1
Tchem
V型质子ATP酶亚基S1(V-type proton ATPase subunit S1)
(1 活性数据)
P2RX3
Tclin
P2X嘌呤受体3(P2X purinoceptor 3)
(1 活性数据)
ELANE
Tclin
Leukocyte elastase
(8173 活性数据)
ADORA3
Tchem
Adenosine A3 receptor
(15931 活性数据)
CTSB
Tchem
Cathepsin B
(3822 活性数据)
ATP6AP1
Tchem
Vacuolar ATP synthase subunit S1
(39 活性数据)
BGC-823
(3035 活性数据)
Caco-2
(12174 活性数据)
MCF7
(126967 活性数据)
PC-3
(62116 活性数据)
A549
(127892 活性数据)
NCI-H460
(60772 活性数据)
HeLa
(62764 活性数据)
SMMC-7721
(5516 活性数据)
TAOK2
Tchem
Serine/threonine-protein kinase TAO2
(964 活性数据)
关联靶点（其它种属）
ATP6V1B2
Vacuolar H(+)-ATPase (27 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
P2rx3
P2X purinoceptor 3 (632 活性数据)
VATB
Adenosinetriphosphatase (4 活性数据)
Salmonella typhimurium (15756 活性数据)
Staphylococcus aureus (210822 活性数据)
Escherichia coli (133304 活性数据)
Cryptococcus neoformans (21258 活性数据)
Candida albicans (78123 活性数据)
Candida parapsilosis (8521 活性数据)
Hepatitis C virus (23859 活性数据)
Murine hepatitis virus (113 活性数据)
Influenza A virus (11224 活性数据)
MDCK (10148 活性数据)
RAW264.7 (28094 活性数据)
3Y1 cell line (119 活性数据)
H4 (48 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Bacillus spizizenii (1898 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
Soluble in methanol, ethanol (0.1 mg/ml), DMSO (0.1 mg/ml), acetone, and chloroform. Insoluble in water.,
密度
1.12
敏感性
对热和光线敏感
分子量
622.800 g/mol
XLogP3
6.000
氢键供体数Hydrogen Bond Donor Count
4
氢键受体数Hydrogen Bond Acceptor Count
9
可旋转键计数Rotatable Bond Count
7
精确质量Exact Mass
622.408 Da
单同位素质量Monoisotopic Mass
622.408 Da
拓扑极表面积Topological Polar Surface Area
135.000 Ų
重原子数Heavy Atom Count
44
形式电荷Formal Charge
0
复杂度Complexity
1060.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
12
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
4
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
4
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P271: 仅在室外或通风良好的地方使用。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P501: 将内容物/容器处理到。。。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
个人防护装备
dust mask type N95 (US),Eyeshields,Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
Small-Molecule Inhibitors: A Practical Guide for Research Selection — A Minimal Evidence Chain and Scenario-Based Validation Framework (Including a Selection Matrix, Case Cards, and Product Tables 1–4)
目录： 技术文章
Furin: A Review of Its Structural Features, Substrate Recognition, and Research Applications
目录： 技术文章
铁死亡与免疫代谢互作的分子基础
目录： 技术文章
Oxidative Stress and Experimental Interpretation Framework for ROS, JC-1, MPTP, and Calcium Indicators in Mitochondrial Function Assessment
目录： 技术文章
How to Determine Whether a Protein Is Suitable for Targeted Degradation: From Degradation Pathway and Molecular Design to Mechanism Validation
目录： 技术文章
自噬信号通路与选择性自噬研究
目录： 技术文章
Membrane Transporters and Ion Channels: How Transmembrane Substance Flux Drives Cellular Signaling and Functional Regulation
目录： 技术文章
Exosome-Related Ingredients in Skincare Products: Sources and Preparation, Quality Control, Evidence of Efficacy, and Safety Assessment
目录： 技术文章
Protein Degradation-Targeting Chimeras (PROTACs): Molecular Design, Degradation Mechanisms, Experimental Evaluation, and Research Tools
目录： 技术文章
From Metabolic Flux to Protein Degradation: How Metabolic Enzymes and Protein Degradation Systems Jointly Regulate Cell Fate
目录： 技术文章
ERAD, ER-phagy, and Cell-Fate Regulation of Misfolded Proteins Under Endoplasmic Reticulum Stress
目录： 技术文章
Regulatory Mechanisms of Aging-Related Nutrient Sensing, Inflammation, and Homeostatic Signaling Pathways
目录： 技术文章
AUTAC or AUTOTAC? Mechanistic Differences Between First- and Second-Generation Autophagy-Targeting Degradation Technologies
目录： 技术文章
From PROTAC to Non-Ubiquitin–Proteasome Degradation: Mechanisms and Selection of LYTAC, ATTEC, AUTAC, and BacPROTAC
目录： 技术文章
此产品的引用文献
引用文献
| 1. Tao Long, Xue Chen, Yue Zhang, Yu-Jia Zhou, Yan-Ni He, Yun-Fei Zhu, Hai-Jun Fu, Lu Yu, Chong-Lin Yu, Betty Yuen-Kwan Law, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou. (2023) Protective effects of Radix Stellariae extract against Alzheimer's disease via autophagy activation in Caenorhabditis elegans and cellular models. BIOMEDICINE & PHARMACOTHERAPY, [PMID:37549461] [10.1016/j.biopha.2023.115261] |
| 2. Yaru Zou, Wei Gao, Huizhen Jin, Chenmei Mao, Yi Zhang, Xiaoling Wang, Dong Mei, Libo Zhao. (2023) Cellular Uptake and Transport Mechanism of 6-Mercaptopurine Nanomedicines for Enhanced Oral Bioavailability. International Journal of Nanomedicine, [PMID:36636639] [10.2147/IJN.S394819] |
| 3. Weizhou Sha, Mingzhu Wang, Wei Wang, Zhi Yuan. (2022) pH-Responsive nanoprobes for tumour fluorescence imaging based on spirolactam rhodamine. Materials Chemistry Frontiers, 6 (19): (2869-2879). [10.1039/D2QM00406B] |
| 4. Weibo Zhang, Shucheng Zhang, Chong Chen, Ning Liu, Dong Yang, Pengjie Wang, Fazheng Ren. (2022) The internalization mechanisms and trafficking of the pea albumin in Caco-2 cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:35764167] [10.1016/j.ijbiomac.2022.06.149] |
| 5. Tao Long, Qian Wu, Jing Wei, Yong Tang, Yan-Ni He, Chang-Long He, Xue Chen, Lu Yu, Chong-Lin Yu, Betty Yuen-Kwan Law, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou. (2022) Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity, [PMID:35242276] [10.1155/2022/3723567] |
| 6. Hongxi Wu, Guodong Li, Weiwei Chen, Wenbin Luo, Zhongyi Yang, Zhipeng You, Yuling Zou. (2021) Drp1 knockdown represses apoptosis of rat retinal endothelial cells by inhibiting mitophagy. ACTA HISTOCHEMICA, [PMID:34959219] [10.1016/j.acthis.2021.151837] |
| 7. Ying Zhang, Qian Liu, Mengting Liu, Xueni Zhang, Xiaoya Li, Lihui Dai, Meng Meng, Dingbin Liu, Yongmei Yin, Rimo Xi. (2021) Dual functional molecule aided background-free SERS sensor for intracellular pH dynamic monitoring based on foldable DNA transition. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2021.131162] |
| 8. Feifei Chen, Lei Guo, Jiehui Di, Man Li, Dong Dong, Dongsheng Pei. (2021) Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling. Journal of Genetics and Genomics, [PMID:34416339] [10.1016/j.jgg.2021.07.017] |
| 9. Wen-Qiao Qiu, Rong Pan, Yong Tang, Xiao-Gang Zhou, Jian-Ming Wu, Lu Yu, Betty Yuen-Kwan Law, Wei Ai, Chong-Lin Yu, Da-Lian Qin, An-Guo Wu. (2020) Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction. BIOMEDICINE & PHARMACOTHERAPY, [PMID:32768883] [10.1016/j.biopha.2020.110575] |
| 10. Xueli Lv, Yaolu Zhu, Yingguang Deng, Shichang Zhang, Qing Zhang, Boxin Zhao, Guofeng Li. (2020) Glycyrrhizin improved autophagy flux via HMGB1-dependent Akt/mTOR signaling pathway to prevent Doxorubicin-induced cardiotoxicity. TOXICOLOGY, [PMID:32525084] [10.1016/j.tox.2020.152508] |
| 11. Lingling Li, Yang Li, Yijing Dang, Tingting Chen, Ao Zhang, Chunyong Ding, Zhiai Xu. (2020) Imidazole-fused benzothiadiazole-based red-emissive fluorescence probe for lysosomal pH imaging in living cells. TALANTA, [PMID:32498855] [10.1016/j.talanta.2020.121066] |
| 12. Yajie Yin, Hailiang Deng, Kai Wu, Bing He, Wenbing Dai, Hua Zhang, Jijun Fu, Yuan Le, Xueqing Wang, Qiang Zhang. (2020) A multiaspect study on transcytosis mechanism of sorafenib nanogranules engineered by high-gravity antisolvent precipitation. JOURNAL OF CONTROLLED RELEASE, [PMID:32278828] [10.1016/j.jconrel.2020.04.008] |
| 13. Sun Yueshan, Jiang Xueqin, Pan Rong, Zhou Xiaogang, Qin Dalian, Xiong Rui, Wang Yiling, Qiu Wenqiao, Wu Anguo, Wu Jianming. (2020) Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells. Frontiers in Pharmacology, [PMID:32158393] [10.3389/fphar.2020.00116] |
| 14. Jin Feng, Yinghui Wu, Lixia Zhang, Ying Li, Songbai Liu, Hua Wang, Chunyang Li. (2019) Enhanced Chemical Stability, Intestinal Absorption, and Intracellular Antioxidant Activity of Cyanidin-3-O-glucoside by Composite Nanogel Encapsulation. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:31466447] [10.1021/acs.jafc.9b04778] |
| 15. Jin-Feng Teng, Da-Lian Qin, Qi-Bing Mei, Wen-Qiao Qiu, Rong Pan, Rui Xiong, Ya Zhao, Betty Yuen-Kwan Law, Vincent Kam-Wai Wong, Yong Tang, Chong-Lin Yu, Feng Zhang, Jian-Ming Wu, An-Guo Wu. (2019) Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer. PHARMACOLOGICAL RESEARCH, [PMID:31404628] [10.1016/j.phrs.2019.104396] |
| 16. Chunlei Zhang, Amin Zhang, Wenxiu Hou, Tianliang Li, Kan Wang, Qian Zhang, Jesús M de la Fuente, Weilin Jin, Daxiang Cui. (2018) Mimicking Pathogenic Invasion with the Complexes of Au22(SG)18-Engineered Assemblies and Folic Acid. ACS Nano, [PMID:29723464] [10.1021/acsnano.8b00196] |
| 17. Ailin Yang, Yanan Zhao, Ying Wang, Xiaojun Zha, Yunfang Zhao, Pengfei Tu, Zhongdong Hu. (2018) Huaier suppresses proliferative and metastatic potential of prostate cancer PC3 cells via downregulation of Lamin B1 and induction of autophagy. ONCOLOGY REPORTS, 39 (6): (3055-3063). [PMID:29658595] [10.3892/or.2018.6358] |
| 18. Haiyan Sun, Maohua Huang, Nan Yao, Jianyang Hu, Yingjie Li, Liping Chen, Nan Hu, Wencai Ye, William Chi-Shing Tai, Dongmei Zhang, Sibao Chen. (2017) The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells. BIOCHEMICAL PHARMACOLOGY, [PMID:29074104] [10.1016/j.bcp.2017.10.012] |
| 19. Feiyang Deng, Hua Zhang, Xing Wang, Yuan Zhang, Hongxiang Hu, Siyang Song, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang, Qiang Zhang. (2017) Transmembrane Pathways and Mechanisms of Rod-like Paclitaxel Nanocrystals through MDCK Polarized Monolayer. ACS Applied Materials & Interfaces, [PMID:28116899] [10.1021/acsami.6b15151] |
| 20. Liu Jie, Su Hua, Qu Qiu-Min. (2016) Carnosic Acid Prevents Beta-Amyloid-Induced Injury in Human Neuroblastoma SH-SY5Y Cells via the Induction of Autophagy. NEUROCHEMICAL RESEARCH, 41 (9): (2311-2323). [PMID:27168327] [10.1007/s11064-016-1945-6] |
| 21. Fang Shi, Yong-Sheng Gao, Shu-Mei Han, Cheng-Suo Huang, Qing-Sheng Hou, Xiao-wen Wen, Ben-Shi Wang, Zhen-Yu Zhu, Lei Zou. (2024) Allulose mitigates chronic enteritis by reducing mitochondria dysfunction via regulating cathepsin B production. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:38354512] [10.1016/j.intimp.2024.111645] |
| 22. Dan Li, Gaoyang Yi, Guifang Cao, Adam C. Midgley, Yongli Yang, Dan Yang, Wenguang Liu, Yujuan He, Xiaolin Yao, Guoliang Li. (2025) Dual-Carriers of Tartary Buckwheat-Derived Exosome-Like Nanovesicles Synergistically Regulate Glucose Metabolism in the Intestine-Liver Axis. Small, [PMID:40079102] [10.1002/smll.202410124] |
| 23. Abdelmoaty Ahmed Attia Ahmed, Chen Jing, Zhang Kun, Wu Changhui, Li Ye, Li Peng, Xu Jianhua. (2024) Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo. Frontiers in Pharmacology, [PMID:39364046] [10.3389/fphar.2024.1422363] |
| 24. Wengui Lu, Chuan Zhang, Yaru Zhang, Ru Xiao, Chaoqi Wei, Fan Zhang, Zhenbao Li, Hewan Xia, Mimi Wan, Zhifei Cheng, Qi Wang. (2025) A programmed Ca2+ nanomodulator by dynamically regulating autophagy and neuroinflammation for Parkinson's disease therapy. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2025.166324] |
| 25. Chen Xue, Zhou Xing-Yue, Lan Cai, Fu Hai-Jun, Li Zhi-Chao, Chen Meng-Yi, Wen Yong-Ping, Yu Lu, Qin Da-Lian, Wu An-Guo, Wu Jian-Ming, Zhou Xiao-Gang. (2025) Araloside A Induces Raf/MEK/ERK-Dependent Autophagy to Mitigate Alzheimer’s and Parkinson’s Pathology in Cellular and C. elegans Models. MOLECULAR NEUROBIOLOGY, [PMID:40742404] [10.1007/s12035-025-05242-4] |
| 26. Yue Zhang, Lan Deng, Jing Wei, Lufen Huang, Fei Gao, Lu Yu, Fengdan Zhu, Jianing Mi, Jianming Wu, Fang Ren, Minsong Guo, Xiaogang Zhou, Dalian Qin, Ting Chen, Anguo Wu. (2025) Gaultheria leucocarpa inhibits Aβ fibrillization and enhances mitophagy-mediated degradation of pathogenic proteins. Neurotherapeutics, [PMID:40817000] [10.1016/j.neurot.2025.e00721] |
| 27. Seongsu Kang, Jiwon Park, Eunbyul Cho, Dohyun Kim, Sanghyun Ye, Eui Taek Jeong, Seung-Hyun Jun, Nae-Gyu Kang. (2025) Distinctive Gene Expression Profiles and Biological Responses of Skin Fibroblasts to Nicotinamide Mononucleotide: Implications for Longevity Effects on Skin. Biomedicines, 13 (10): (2395). [PMID:41153679] [10.3390/biomedicines13102395] |
| 28. Dan Li, Rong Shao, Na Wang, Nan Zhou, Kaili Du, Jiahui Shi, Yihan Wang, Zhuangzhuang Zhao, Xin Ye, Xiaoli Zhang, Haoxing Xu. (2020) Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress. Autophagy, [PMID:32138578] [10.1080/15548627.2020.1739442] |
| 29. Ru Li, Yimei Ma, Anqi He, Yamin Pu, Xuanting Wan, Hongbao Sun, Ningyu Wang, Min Luo, Guan Wang, Yong Xia. (2025) Fasting enhances the efficacy of Sorafenib in breast cancer via mitophagy mediated ROS-driven p53 pathway. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:39864757] [10.1016/j.freeradbiomed.2025.01.047] |
| 30. Yun-Fei Zhu, Xing-Yue Zhou, Cai Lan, Yong-Ping Wen, Hai-Jun Fu, Zhi-Chao Li, Ya-Ping Li, Shi-Ying Li, Fei-Hong Huang, Long Wang, Lu Yu, Da-Lian Qin, An-Guo Wu, Jian-Ming Wu, Xiao-Gang Zhou. (2025) Tricin Delays Aging and Enhances Muscle Function via Activating AMPK-Mediated Autophagy in Diverse Model Organisms. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:40243450] [10.1021/acs.jafc.4c12619] |
| 31. Hongtao Tie, Mengqian Hou, Jun Zhang, Martijn F. Hoes, Dietbert Neumann, Joost J. F. P. Luiken, Shujin Wang. (2026) Comprehensive methodological evaluation of V-ATPase assembly in the context of cardiac lipid overload: implications for (endo)lysosomal function and autophagy. Autophagy, [PMID:41432243] [10.1080/15548627.2025.2608963] |
| 32. Shaoqin Cen, Zhenxing Hou, Yuan Zhang, Nan Wang, Zihe Zhao, Ao Li, Guoqiang Wan, Tianhong Zhang, Xia Gao. (2026) Obacunone mitigates cisplatin-induced ototoxicity by activating CRHBP-mediated autophagy. BIOCHEMICAL PHARMACOLOGY, [PMID:41611132] [10.1016/j.bcp.2026.117759] |
| 33. Yan-Ni He, Shi-Ying Li, Pei Xu, Xing-Yue Zhou, Jing Zeng, Da-Lian Qin, Geng Xiong, Lu Yu, Wei Ren, An-Guo Wu, Jian-Ming Wu, Xiao-Gang Zhou. (2026) Salvia plebeia R. Br. extract delays cellular senescence and promotes healthy aging via Atg7-dependent autophagy, with rosmarinic acid as a major bioactive constituent. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, [PMID:41722623] [10.1016/j.jnutbio.2026.110315] |
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）