计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 4269 篇同行评审文献引用。
概述
Information
Vitamin C (Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.
In vitro
Ascorbate when combined with copper rapidly reduces the viscosity of DNA solutions and has exhibited some carcinostatic effects on transplanted sarcoma 180 tumours in mice. Exposure of HL-60 cells to increasing concentrations of H2O2 results in dose-dependent intracellular accumulation of peroxides, which is accompanied by a decrease in intracellular ascorbic acid and an increase in apoptosis. Ascorbic acid loading also provides strong protection from apoptosis associated with serum- and glucose-free culture of HL-60 cells. Vitamin C is found to protect GSH-depleted HL-60 cells in a dose-dependent manner. Vitamin C inhibits the formation of ROS in both normal and GSH-depleted cells. Ascorbate (1 mM) generates 161 mM H2O2 in Dulbecco\'s modified Eagle\'s medium and induces apoptosis in 50% of HL60 cells, whereas in RPMI 1640 only 83 mM H2O2 is produced and no apoptosis is detected.
In vivo
Treatment of rats with Vitamin C 10 min prior to the cisplatin inhibits cisplatin-mediated damage. The enhanced serum creatinine levels which are indicative of renal injury shows a significant reduction with the three doses of Vitamin C tested.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
别名
维生素C
英文别名
Ascorbic acid | (R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Vitamin C
生化机理
维生素 C（抗坏血酸）是一种水溶性维生素，用于预防和治疗坏血病。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
200-066-2
分子类型
小分子
Isomeric SMILES
C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
NSC Number
UN 1648
UN Number
MeSH Entry Terms
Acid, Ascorbic;Acid, L-Ascorbic;Ascorbate, Ferrous;Ascorbate, Magnesium;Ascorbate, Sodium;Ascorbic Acid;Ascorbic Acid, Monosodium Salt;di-L-Ascorbate, Magnesium;Ferrous Ascorbate;Hybrin;L Ascorbic Acid;L-Ascorbic Acid;Magnesium Ascorbate;Magnesium Ascorbi
分子量
176.12
Beilstein号
84272
Reaxy-Rn
84272
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=84272&ln=
技术文档
高级数据
关联靶点（人）
ADRA2B
Tclin
α-2B 肾上腺素受体(Alpha-2B adrenergic receptor)
(1 活性数据)
化学和物理性质
比旋光度
21 ° (C=10, H2O)
熔点
190-192°C
安全和危险性（GHS）
信号词
警告
危险声明
H226: 易燃液体和蒸气
H302: 吞食有害
H319: 引起严重眼睛刺激
H313+H333: 接触皮肤或吸入可能有害。
预防措施声明
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。
P233: 保持容器密闭。
P240: 地面/粘结容器和接收设备
P241: 使用防爆的[电气/通风/照明/.../]设备。
P242: 仅使用无火花的工具。
P243: 采取防静电措施
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P312: 打电话给毒物中心或医生。。。如果你觉得不舒服
P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。
P304+P312: 如果吸入：如果感到不适，请呼叫解毒中心/医生/...。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P337+P313: 如仍觉眼刺激：求医/就诊。
P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。
P403+P235: 存放在通风良好的地方。保持低温。
P501: 将内容物/容器处理到。。。
P301+P312+P330: 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口
WGK Germany
1
RTECS
CI7650000
Class
II
Merck Index
830
个人防护装备
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 J2620001 |
分析证书 | V408646 |
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此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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