计算溶液所需的质量、体积或浓度。
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 324 篇同行评审文献引用。
概述
Information
Acetylcysteine (N-acetyl-l-cysteine, NAC) is aROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also atumor necrosis factor productioninhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-inducedN
In vitro
N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity. N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism.
In vivo
N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
NAC | N-acetyl-L-cysteine
规格或纯度
Moligand™, 10mM in DMSO
英文名称
N-Acetyl-L-Cysteine(NAC)
生化机理
乙酰半胱氨酸（N-acetyl-l-cysteine，NAC）是一种 ROS（活性氧）抑制剂，可拮抗蛋白酶体抑制剂的活性。它还是一种肿瘤坏死因子生成抑制剂。乙酰半胱氨酸（N-乙酰-L-半胱氨酸）通过抑制 IκB 激酶抑制 TNF 诱导的 NF-κB 激活。乙酰半胱氨酸（N-乙酰-L-半胱氨酸）通过线粒体依赖途径诱导细胞凋亡。乙酰半胱氨酸（N-乙酰-L-半胱氨酸）可抑制铁变态反应和病毒复制。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
调节剂
作用机制
溶菌酶
名称和识别符
EC号
210-498-3
分子类型
小分子
Isomeric SMILES
CC(=O)N[C@@H](CS)C(=O)O
分子量
163.19
Beilstein号
1724426
Reaxy-Rn
1724426
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1724426&ln=
技术文档
高级数据
产品属性
| ALogP | 0.4 |
|---|
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 64 mg/mL (198.51 mM); Ethanol: 64 mg/mL (198.51 mM); Water: Insoluble;
比旋光度
24 ° (JPC Method)
熔点
109-111°C
安全和危险性（GHS）
象形图
信号词
Warning
危险声明
H319: 引起严重眼睛刺激
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P302+P352: 如皮肤沾染：用水充分清洗。
P321: 特殊处理（请参阅此标签上的...）。
P405: 密闭存放
P501: 将内容物/容器处理到。。。
P264: 处理后要彻底洗手。
P271: 仅在室外或通风良好的地方使用。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P403+P233: 存放在通风良好的地方。保持容器密闭。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
2
RTECS
HA1660000
Merck Index
88
个人防护装备
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 E2417006 |
分析证书 | A408248 |
技术文档和文章
Small-Molecule Inhibitors: A Practical Guide for Research Selection — A Minimal Evidence Chain and Scenario-Based Validation Framework (Including a Selection Matrix, Case Cards, and Product Tables 1–4)
目录： 技术文章
A Practical Guide to Small-Molecule Chemical Probes: Concept Clarification, Causal Validation, and Experimental Selection (with Product Navigation and Tables A–D)
目录： 技术文章
From Piperidine to Pyridine: The “Most Common N-Heterocycle” Shift in FDA Small-Molecule New Drugs (2013–2023) and a Selection Guide (Tables 1–4)
目录： 技术文章
Pyridinones as “Property Knobs” in Drug Design: From Tautomers and H-Bonding Fingerprints to Product Selection (Tables A–C)
目录： 技术文章
Amino Acid Oxidases: Oxygen-Dependent Oxidative Deamination Systems and Their Analytical and Applied Uses
目录： 技术文章
Glutaraldehyde-mediated Microbial Inactivation: Chemical Mechanisms, Determinants, and Key Validation Considerations
目录： 技术文章
Review of the Structural Characteristics, Biological Functions, and Application Advances of Lycopene
目录： 技术文章
Functional System Overview of Cellular Metabolic Enzymes in Energy Metabolism, Redox, and Signal Transduction
目录： 技术文章
Roles of One-Carbon Metabolism Enzymes in Oxidative Stress and Epigenetic Regulation in Cardiovascular Diseases
目录： 技术文章
The Drug Target Potential of the GPX Family in Lipid Peroxidation Defense, Ferroptosis Regulation, and Organ Injury Protection
目录： 技术文章
Coupling Mechanisms Between Terminal Reducing-Power Allocation in Photosynthetic Electron Transport and Metabolic Demand
目录： 技术文章
铁死亡与免疫代谢互作的分子基础
目录： 技术文章
Oxidative Stress and Experimental Interpretation Framework for ROS, JC-1, MPTP, and Calcium Indicators in Mitochondrial Function Assessment
目录： 技术文章
Research Progress on the Moonlighting Functions of Carbohydrate-Metabolic Enzymes in Replication Programs, DNA Damage Repair, and Inflammatory Activation
目录： 技术文章
氧化应激相关研究进展汇总
目录： 技术文章
Mechanistic Analysis of Topical Glutathione in Skincare: Cellular Redox Regulation, Skin Delivery Challenges, and SLN-Based Delivery Strategies
目录： 技术文章
自噬信号通路与选择性自噬研究
目录： 技术文章
Antioxidant Mechanisms, Stability, and Delivery Strategies of Resveratrol in Skincare Research
目录： 技术文章
Antioxidant Mechanisms of Ferulic Acid in Skincare, Vitamin C/E Synergy, and Stable Delivery Applications
目录： 技术文章
Membrane Transporters and Ion Channels: How Transmembrane Substance Flux Drives Cellular Signaling and Functional Regulation
目录： 技术文章
Analysis of the Canonical and Non-Canonical NF-κB Pathways: Activation Mechanisms, Detection Methods, and Research Tool Selection
目录： 技术文章
How Do Collagen Peptides Act on the Skin? From Surface Hydration and Percutaneous Delivery to Fibroblasts and Collagen Homeostasis
目录： 技术文章
Anti-Photoaging Potential of Artemia Extract: UV-Induced Damage Cascades, HSP70-Related Stress Protection, and GP4G Metabolic Insights
目录： 技术文章
Exosome-Related Ingredients in Skincare Products: Sources and Preparation, Quality Control, Evidence of Efficacy, and Safety Assessment
目录： 技术文章
Gentiana Root Extract and Gentiopicroside: Chemical Composition, Antioxidant and Inflammation-Modulating Mechanisms, and Their Potential Effects on Skin Barrier Homeostasis
目录： 技术文章
From Metabolic Flux to Protein Degradation: How Metabolic Enzymes and Protein Degradation Systems Jointly Regulate Cell Fate
目录： 技术文章
How Does Collagen Tripeptide Act on the Skin: Stratum Corneum Delivery, Matrix Protection, and Regulation of Collagen Homeostasis
目录： 技术文章
Structure–Function Relationships of Ganoderma lucidum Extract: Skin-Protective Effects of Polysaccharides and Triterpenoids and Formulation Delivery Strategies
目录： 技术文章
Structural Characteristics of Ergothioneine, OCTN1-Mediated Uptake by Skin Cells, and Antioxidant Mechanisms
目录： 技术文章
Are Lipids Fats? Understanding the Multiple Functions of Lipids from Cellular Metabolism to mRNA Delivery
目录： 技术文章
Why Proximity to Cysteine Does Not Necessarily Lead to Covalent Bond Formation: Warhead Reactivity, Reaction Geometry, and Target-Site Microenvironment
目录： 技术文章
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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