E2427407计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
UltraBio™,超纯级 提供 ≥99%(T) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温。 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1151 篇同行评审文献引用。
概述
甘氨酸用于全细胞膜片钳记录，以测量NMDA（N-甲基-D-天冬氨酸）内向电流。它还用作结晶学中的模型有机系统，展示新型声学雾化平台。
应用
在扫描电子显微镜的样品（核）制备过程中，甘氨酸被用于淬灭未反应的醛。也用于免疫标记过程中的样品固定
Gene Information
rat ... Grin2a(24409)
Application
Glycine has been used to quench unreacted aldehyde during sample (nuclei) preparation for scanning electron microscope. It has also been used for sample fixation in the process of immunolabeling.
规格
别名
乙氨酸, 氨基乙酸, 氨基醋酸
英文别名
EINECS 200-272-2 | Aciport | Padil | [3H]glycine | GLYCINE (USP MONOGRAPH) | Glycine [USP:INN] | Tocris-0219 | GLYCINE (USP-RS) | Glycine iron sulphate (1:1) | AI3-04085 | GLYCINE [VANDF] | H2N-CH2-COOH | CHEBI:15428 | [14C]glycine | [14C]-glycine | Amino
规格或纯度
UltraBio™, 超纯级, ≥99%(T)
英文名称
Glycine
生化机理
甘氨酸是非必需氨基酸。通过细胞膜的钙内流由甘氨酸门控通道介导。甘氨酸参与卟啉、嘌呤和丝氨酸的合成。它还可作为谷氨酸与NMDA（N-甲基-D-天冬氨酸）受体结合的竞争性激动剂。在快速增殖的癌细胞中，由于对氨基酸的需求增加，甘氨酸合成可能会增加。
脊髓中的抑制性神经递质，NMDA受体的变构调节器。
储存条件
室温
纯度
≥99%(T)
名称和识别符
PubChem SID
EC号
200-272-2
分子类型
小分子
IUPAC Name
2-aminoacetic acid
INCHI
1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChi Key
DHMQDGOQFOQNFH-UHFFFAOYSA-N
Smiles
C(C(=O)O)N
Isomeric SMILES
C(C(=O)O)N
分子量
75.07
Beilstein号
635782
Reaxy-Rn
635782
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=635782&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机酸及其衍生物 |
| 类（Class) | 羧酸及其衍生物 |
| 亚类（Subclass） | 氨基酸、肽和类似物 |
| 中间层级节点（Intermediate Tree Nodes） | 氨基酸及其衍生物 - α氨基酸及其衍生物 |
| 直接上位类(Direct Parent) | α氨基酸 |
| 其他上位类（Alternative Parents） | 氨基酸 一元羧酸及其衍生物 羧酸 有机光子化合物 有机氧化物 单烷基胺 碳氢化合物衍生物 羰基化合物 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 脂肪族非环化合物 - α-氨基酸 - 氨基酸 - 氨基酸 - 羰基 - 羧酰胺基 - 烃衍生物 - 单羧酸或其衍生物 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 - 初级脂肪胺 - 初级胺 |
| 描述（Description） | 该化合物属于α-氨基酸类有机化合物。此类氨基酸的氨基直接连接于羧基相邻的碳原子（α碳）。 |
| 外部描述符（External Descriptors） | Common amino acids - Amino acids |
三维结构
交互式化学结构模型
关联靶点（人）
GPRC6A
Tchem
G 蛋白偶联受体家族 C 组 6 成员 A(G-protein coupled receptor family C group 6 member A)
(1 活性数据)
PDE5A
Tclin
Phosphodiesterase 5A
(5113 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
F2
Tclin
Thrombin
(11687 活性数据)
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
HMGCR
Tclin
HMG-CoA reductase
(2475 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
INSR
Tclin
Insulin receptor
(5558 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
ACE
Tclin
Angiotensin-converting enzyme
(1423 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
GABRA1
Tclin
GABA receptor alpha-1 subunit
(399 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
DRD4
Tchem
Dopamine D4 receptor
(7907 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
ADRA1D
Tclin
Alpha-1d adrenergic receptor
(4171 活性数据)
HTR1B
Tclin
Serotonin 1b (5-HT1b) receptor
(2801 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
SLC6A1
Tclin
GABA transporter 1
(308 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
CALCR
Tclin
Calcitonin receptor
(2215 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
ADRA1B
Tclin
Alpha-1b adrenergic receptor
(2912 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
HTR3A
Tclin
Serotonin 3a (5-HT3a) receptor
(3366 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
GRIN1
Tclin
Glutamate (NMDA) receptor subunit zeta 1
(122 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
HTR4
Tclin
Serotonin 4 (5-HT4) receptor
(2068 活性数据)
PDE3A
Tclin
Phosphodiesterase 3A
(3309 活性数据)
关联靶点（其它种属）
Agtr2
Angiotensin II type 2 (AT-2) receptor (803 活性数据)
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Ltc4s
Leukotriene C4 synthase (1 活性数据)
Sigmar1
Sigma opioid receptor (160 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Nos2
Nitric oxide synthase, inducible (3573 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Slc6a9
Glycine transporter 1 (255 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Mmp9
Matrix metalloproteinase 9 (38 活性数据)
Glra1
Glycine receptor subunit alpha-1 (65 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
Slc6a11
GABA transporter 4 (930 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Chrna3
Neuronal acetylcholine receptor; alpha3/beta4 (1368 活性数据)
Grin1
Glutamate NMDA receptor (6467 活性数据)
Slc16a10
Monocarboxylate transporter 10 (73 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
Grin1
Glutamate NMDA receptor; Grin1/Grin2b (1028 活性数据)
Grin1
Glutamate NMDA receptor; Grin1/Grin2a (798 活性数据)
Grin1
Glutamate NMDA receptor; Grin1/Grin2c (1127 活性数据)
Glra2
Glycine receptor (1745 活性数据)
Slc1a5
Amino acid transporter (271 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
1 M HCl：1M，透明，无色
熔点
240 °C
分子量
75.070 g/mol
XLogP3
-3.200
氢键供体数Hydrogen Bond Donor Count
2
氢键受体数Hydrogen Bond Acceptor Count
3
可旋转键计数Rotatable Bond Count
1
精确质量Exact Mass
75.032 Da
单同位素质量Monoisotopic Mass
75.032 Da
拓扑极表面积Topological Polar Surface Area
63.300 Ų
重原子数Heavy Atom Count
5
形式电荷Formal Charge
0
复杂度Complexity
42.900
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
信号词
警告
危险声明
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
WGK Germany
1
RTECS
MB7600000
Merck Index
4491
个人防护装备
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
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此产品的引用文献
溶液计算器
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