J2627477计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
概述
胆固醇是一种少量存在于植物中的固醇。它主要与植物膜相连，是叶片表面脂质的一种组成成分。
应用：
胆固醇已被用于：
制备小单层脂质体
生成百里醌（TQ）负载脂质体以进入白色念珠菌感染的鼠模型中
制备用于结构光学显微镜研究的小单层脂质体
Cholesterol is a minor sterol present in plants. It is majorly associated with the plant membranes and is a constituent of leaf surface lipids.
Application：
Cholesterol has been used:
in the preparation of small unilamellar vesicles
in the generation of thymoquinone (TQ) loaded liposomes for administering into murine model with Candida albicans infection
in the preparation of small unilamellar vesicles for structured illumination microscopy studies
规格
别名
胆甾醇 | 3β-羟基-5-胆甾烯 | 5-胆甾烯-3β-醇
英文别名
5-Cholesten-3β-ol | 3β-Hydroxy-5-cholestene
规格或纯度
无动物源, 低内毒素, 用于细胞培养, ≥99%
英文名称
Cholesterol
储存条件
避光,-20°C储存,充氩
运输条件
超低温运输
纯度
≥99%
名称和识别符
EC号
200-353-2
分子类型
小分子
IUPAC Name
(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
INCHI
1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChi Key
HVYWMOMLDIMFJA-DPAQBDIFSA-N
Smiles
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Isomeric SMILES
C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
分子量
386.65
Beilstein号
1915888
Reaxy-Rn
2060565
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2060565&ln=
高级数据
系统学分类
分类树（Taxonomy Tree）
-
界（kingdom)
有机化合物
-
超类（Superclass)
脂质和脂质样分子
-
类（Class)
类固醇和类固醇衍生物
- 亚类（Subclass） 胆甾烷类固醇
-
类（Class)
类固醇和类固醇衍生物
-
超类（Superclass)
脂质和脂质样分子
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 脂质和脂质样分子 |
| 类（Class) | 类固醇和类固醇衍生物 |
| 亚类（Subclass） | 胆甾烷类固醇 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 胆固醇及其衍生物 |
| 其他上位类（Alternative Parents） | 3-β-羟基类固醇 3-β-羟基δ-5-类固醇 Delta-5-类固醇 仲醇 环状醇及其衍生物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 脂肪族同多环化合物 |
| 取代基（Substituents） | 3-β-羟基-δ-5-甾体 - 3-β-羟基类固醇 - 3-羟基-δ-5-甾体 - 3-羟基-4-烷基-10-羟基- - 羟基苯甲酸酯 - 脂肪族同多环化合物 - 胆固醇 - 胆固醇骨架 - 环醇 - Delta-5-类固醇 - 烃衍生物 - 羟基吡啶 - 有机氧化合物 - 有机氧化合物 - 醛基 |
| 描述（Description） | 该化合物属于胆固醇及其衍生物类有机化合物。这类化合物具有3-羟基胆烷骨架结构。 |
| 外部描述符（External Descriptors） | Cholesterol and derivatives |
三维结构
交互式化学结构模型
关联靶点（人）
CYP46A1
Tchem
胆固醇24-羟化酶(Cholesterol 24-hydroxylase)
(2 活性数据)
RORC
Tchem
核受体ROR-gamma(Nuclear receptor ROR-gamma)
(1 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
CYP11A1
Tclin
Cytochrome P450 11A1
(1 活性数据)
POLA1
Tclin
DNA polymerase alpha subunit
(225 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
NPC1L1
Tclin
Niemann-Pick C1-like protein 1
(346 活性数据)
POLB
Tchem
DNA polymerase beta
(23632 活性数据)
NR1H3
Tchem
LXR-alpha
(2891 活性数据)
CCRF-CEM
(65223 活性数据)
HL-60
(67320 活性数据)
HT-29
(80576 活性数据)
MCF7
(126967 活性数据)
SH-SY5Y
(11521 活性数据)
SW480
(6023 活性数据)
U-937
(7138 活性数据)
A549
(127892 活性数据)
BJ
(6930 活性数据)
T47D
(39041 活性数据)
NCI-H69
(709 活性数据)
HCT-116
(91556 活性数据)
KB
(17409 活性数据)
HeLa
(62764 活性数据)
MDA-MB-231
(73002 活性数据)
SMMC-7721
(5516 活性数据)
ABCG2
Tchem
ATP-binding cassette sub-family G member 2
(4927 活性数据)
SNCA
Tchem
Alpha-synuclein
(10960 活性数据)
LMNA
Tbio
Prelamin-A/C
(36751 活性数据)
SLCO1B1
Tchem
Solute carrier organic anion transporter family member 1B1
(2672 活性数据)
SLCO1B3
Tchem
Solute carrier organic anion transporter family member 1B3
(2517 活性数据)
SULT2B1
Tbio
Sulfotransferase family cytosolic 2B member 1
(4 活性数据)
IDH1
Tclin
Isocitrate dehydrogenase [NADP] cytoplasmic
(40980 活性数据)
CYP46A1
Tchem
Cholesterol 24-hydroxylase
(289 活性数据)
关联靶点（其它种属）
ERG11
Cytochrome P450 51 (617 活性数据)
Ppard
Peroxisome proliferator-activated receptor delta (358 活性数据)
Abcb1b
P-glycoprotein 1 (174 活性数据)
Top2
DNA topoisomerase II (15 活性数据)
Salmonella typhimurium (15756 活性数据)
Staphylococcus aureus (210822 活性数据)
Escherichia coli (133304 活性数据)
Streptococcus pyogenes (16140 活性数据)
Bacillus sp. (164 活性数据)
Mycobacterium tuberculosis (203094 活性数据)
Cutibacterium acnes (887 活性数据)
Rattus norvegicus (775804 活性数据)
P19 (309 活性数据)
Vero (26788 活性数据)
C2C12 (756 活性数据)
cyp125
Putative cytochrome P450 125 (56 活性数据)
env
Envelope glycoprotein (1 活性数据)
Phytophthora cactorum (113 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
Brucella pseudogrignonensis (43 活性数据)
Rorc
Nuclear receptor ROR-gamma (89407 活性数据)
Scn2a
Sodium channel alpha subunits; brain (Types I, II, III) (344 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
密度
1.067
敏感性
对空气、湿气、热、光敏感
比旋光度
-37 ° (C=2, Dioxane)
沸点
360°C
熔点
148.5°C
分子量
386.700 g/mol
XLogP3
8.700
氢键供体数Hydrogen Bond Donor Count
1
氢键受体数Hydrogen Bond Acceptor Count
1
可旋转键计数Rotatable Bond Count
5
精确质量Exact Mass
386.355 Da
单同位素质量Monoisotopic Mass
386.355 Da
拓扑极表面积Topological Polar Surface Area
20.200 Ų
重原子数Heavy Atom Count
28
形式电荷Formal Charge
0
复杂度Complexity
591.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
8
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
WGK Germany
1
RTECS
FZ8400000
Merck Index
2201
个人防护装备
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
代谢性疾病动物模型构建技术详解
目录： 技术文章
用于细胞培养
目录： 阿拉丁试剂的规格、级别和纯度
关于血清的常见问答
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神经类固醇与中枢神经系统保护机制
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The Moisturizing and Low-Moisture Protective Mechanisms of Trehalose: From Its α,α-1,1 Structure and Hydration Dynamics to In Vitro Skin Barrier Research
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Protective and Potential Reparative Mechanisms of Prinsepia utilis Seed Oil on the Skin Barrier: Fatty Acid Composition, Epidermal Lipid Metabolism, and Research Evidence
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Mechanism of Action of Porous Silica in Oil-Control Loose Powder: Pore Structure, Capillary Imbibition, and Surface Modification
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Anti-Photoaging Potential of Artemia Extract: UV-Induced Damage Cascades, HSP70-Related Stress Protection, and GP4G Metabolic Insights
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此产品的引用文献
溶液计算器
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