D2423347计算溶液所需的质量、体积或浓度。
有货
为什么选择此级别
适用于多肽合成 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,室温,充氩。DG运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 446 篇同行评审文献引用。
概述
应用：
N,N-二异丙基乙胺(DIPEA)，也称为Hünig′碱，是一种空间位阻胺。它常被用作多肽合成中的碱。此外，DIPEA还被用于Pd-催化的交叉偶联反应，包括Heck偶联和Sonagashira偶联反应。
N -Ethyldiisopropylamine (EDIA) reacts with monoactivated Michael acceptors to afford symmetrical sulfones.
Application：
N,N-Diisopropylethylamine (DIPEA), also known as Hünig′s base, is a sterically hindered amine. It is commonly employed as a base in peptide synthesis. Additionally, DIPEA is also used in the Pd-catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.
规格
别名
DIPEA,N,N-二异丙基乙胺, Hünig 碱
英文别名
diisopropylethylarnine | diisoproplyethylamine | EtNiPr2 | i-Pr2EtN | N-(4-chlorobenzyl)piperazine | N-ethyidiisopropylamine | N-ethyl-N-isopropyl-propan-2-amine | N-ethyl-N-isopropylpropan-2-amine | 1H-Imidazol-2-amine xsulfate | (S)-2-((S)-2-Amino-3-phe
规格或纯度
适用于多肽合成, ~2 M in 1-methyl-2-pyrrolidinone
英文名称
N-Ethyldiisopropylamine solution
储存条件
避光,室温,充氩
运输条件
DG运输
名称和识别符
PubChem SID
EC号
230-392-0
分子类型
小分子
IUPAC Name
N-ethyl-N-propan-2-ylpropan-2-amine
INCHI
1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
InChi Key
JGFZNNIVVJXRND-UHFFFAOYSA-N
Smiles
CCN(C(C)C)C(C)C
Isomeric SMILES
CCN(C(C)C)C(C)C
UN Number
Packing Group
I
分子量
129.24
Beilstein号
4124745
Reaxy-Rn
605301
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=605301&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机氮化合物 |
| 类（Class) | 有机氮化合物 |
| 亚类（Subclass） | 胺类 |
| 中间层级节点（Intermediate Tree Nodes） | 叔胺 |
| 直接上位类(Direct Parent) | 三烷基胺 |
| 其他上位类（Alternative Parents） | 有机光子化合物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 脂肪族非环化合物 - 烃衍生物 - 有机氮化合物 - 三元脂肪胺 |
| 描述（Description） | 该化合物属于有机化合物中的三烷基胺类。这类化合物含有三烷基胺基团，其特征在于三个烷基基团精确地与氨基氮原子相连。 |
| 外部描述符（External Descriptors） | 暂无 |
三维结构
交互式化学结构模型
化学和物理性质
敏感性
对光线敏感；对空气敏感；易吸潮
折光率
1.414
闪点(℉)
51.08 ℉
闪点(℃)
10.6°C
沸点
127°C
熔点
-45 °C
分子量
129.240 g/mol
XLogP3
2.200
氢键供体数Hydrogen Bond Donor Count
0
氢键受体数Hydrogen Bond Acceptor Count
1
可旋转键计数Rotatable Bond Count
3
精确质量Exact Mass
129.152 Da
单同位素质量Monoisotopic Mass
129.152 Da
拓扑极表面积Topological Polar Surface Area
3.200 Ų
重原子数Heavy Atom Count
9
形式电荷Formal Charge
0
复杂度Complexity
59.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
一般危化品
一般危化品
信号词
危险
危险声明
H226: 易燃液体和蒸气
H302: 吞食有害
H314: 造成严重的皮肤灼伤和眼睛损伤
H331: 吸入会中毒
H335: 可能引起呼吸道刺激
H360: 可能损害生育力或未出生的孩子
H402: 对水生生物有害
H411: 对水生生物有毒并具有长期持续影响
预防措施声明
P201: 使用前获取特殊说明
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。
P202: 在阅读并理解所有安全预防措施之前，不要进行操作。
P233: 保持容器密闭。
P240: 地面/粘结容器和接收设备
P241: 使用防爆的[电气/通风/照明/.../]设备。
P242: 仅使用无火花的工具。
P243: 采取防静电措施
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P271: 仅在室外或通风良好的地方使用。
P273: 避免释放到环境中。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P363: 再次使用之前，请清洗受污染的衣物。
P391: 收集溢出物
P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。
P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P308+P313: 如接触到或有疑虑：求医/就诊。
P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。
P403+P233: 存放在通风良好的地方。保持容器密闭。
P403+P235: 存放在通风良好的地方。保持低温。
P501: 将内容物/容器处理到。。。
P301+P312+P330: 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口
WGK Germany
2
Class
6.1 (3)
个人防护装备
Faceshields,full-face respirator (US),Gloves,Goggles,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
技术文档和文章
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From Analytical Instrument to Synthetic Platform: A New Strategy for Reconstructing Automated Flow Solid-Phase Peptide Synthesis with Standard Analytical HPLC
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Understanding ATD-DMAP: From Reagent Design to Esterification, Amidation, and Stereochemical Integrity
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Selective Deprotection and Sulfonyl Group Migration of N-Aryl Sulfonamides Mediated by TfOH (Trifluoromethanesulfonic Acid): Reaction Patterns and Synthetic Implications
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The Positioning of TBTU in Practice: Racemization Risk, Extended Uses, and Selection Criteria
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From “High Yield” to “Configuration Retention”: Activation-Stage Risks, Route Differences, and Selection Principles for Coupling Systems
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The Methodological Value of HATU in Difficult Couplings: Reactivity Advantages, Stereochemical Retention, and Condition Management
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Low Racemization in Peptide Synthesis Is Not Just About Reagent Choice: Stereochemical Risk During the Activation Stage and Practical Strategies for Experimental Control
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The Methodological Value of TCFH: Advantages in Challenging Amidation and the Switching Logic of Carboxylic Acid Activation Pathways
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Low-Racemization Control in Peptide Synthesis: An Inverse N→C Peptide Synthesis Strategy via Activated α-Aminoesters
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Ynamide Coupling Reagents: From Low-Epimerization Activation Pathways to More Practically Usable N→C Inverse Peptide Synthesis
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Decision Logic for Peptide Synthesis Routes: Applicability and Criteria for Choosing among SPPS, LPPS, and Recombinant Expression
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Decision Logic for Selecting Coupling Reagents in Amide Bond Formation: Activation Pathways, Side Reactions, Epimerization, Workup, and Safety
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Experimental Selection Logic for Carboxylic Acid Preactivation Pathways: Differences and Suitable Use Cases for Classical Mixed Anhydrides, CDI, Sulfonyl Chloride Systems, and the Yamaguchi System
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Reaction Roles of DBU in Different Systems: Experimental Judgment from a Strong Organic Base to Nucleophilic Catalysis and Participation in the Reaction Pathway
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Boc₂O Selection Cannot Be Judged by Protection Installation Alone: Experimental Decision-Making from Substrate Nucleophilicity and Medium Effects to Deprotection Pathways
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DMAP Is More Than Just an Organic Base: Experimental Judgment from Nucleophilic Acyl Transfer to Esterification and Macrolactonization
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Experimental Assessment of HOPO in Carbodiimide-Mediated Amide Coupling: Low-Racemization Control, Application Scenarios, and Process Considerations
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Experimental Selection Logic for Pentafluorophenyl-Based Systems: Practical Judgment from Active Esters and Pre-Activated Monomers to Downstream Transformations
目录： 技术文章
Experimental Selection of SEM-Cl: From O/N-SEM Protection and Directed Functionalization of N-Heterocycles to the Introduction of Protected C1 Fragments
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Experimental Judgment in Oxyma Coupling Systems: Coupling Efficiency, Racemization Control, and the HCN Risk in DIC-Based Systems
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Experimental Evaluation of Triphosgene in Organic Synthesis: Understanding Its Selection Logic Through Reaction Tasks
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Triphenylphosphine-Involved Carboxylic Acid Activation and Amide Bond Formation: Activation Pathways, Anhydride Competition, and Applicability Scenarios
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Experimental Judgment for CMPI in Carboxylic Acid Activation: Applicable Tasks, Base Matching, and Workup Burden
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Experimental Judgment and Condition Selection for Visible-Light Catalysis in Organic Synthesis
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Reaction Selection in Small-Molecule Synthesis: From Transformation-Type Assessment to Experimental Route Screening
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How to Troubleshoot Abnormal Impurities in Peptide Synthesis? Locating Process Issues Through Amino-Related Side Reactions
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AITF-Mediated Carboxylic Acid Activation for the Synthesis of Amides, Peptides, and Esters: Activation Mechanism and Applicable Scenarios
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Stabilization Design of Bridgehead α-Fluoroamines and Their Value as Medicinal Chemistry Building Blocks
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How Cyclization Changes Peptide Behavior: Conformational Preorganization, Skin Delivery, and Integrin Binding, Using Cyclopeptide-5 as an Example
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1,8-Naphthyridine-Based Aldose Reductase Inhibitors: Scaffold Construction, In Vitro Inhibitory Activity, and Directions for Structural Optimization
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Why Primary and Secondary Amines Have Difficulty Participating Directly in the Classical Mitsunobu Reaction: Mechanism, Inversion of Configuration, and Reaction Scope of BEHT-Mediated Alcohol Amination
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Storage Stability and Deoxyfluorination Reactivity of ImCl[H₂F₃]—Reactivity Modulation of the H₂F₃⁻ Fluoride Source and Substrate Activation by 2-Chloroimidazolium
目录： 技术文章
此产品的引用文献
溶液计算器
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