计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
有货
为什么选择此级别
分子生物学级 提供 ≥98.5%(GC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温,干燥。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1833 篇同行评审文献引用。
概述
有特殊气味。溶于水呈不透明溶液，溶液呈中性。能乳化脂肪。有湿热空气中分解。有光滑感。1g溶于10ml水中，形成乳状液，水溶液表面张力小，呈中性反应，部分溶于乙醇，几乎不溶于氯仿、乙醚和轻石油。低毒，半数致死量(大鼠，经口)1288mg/kg。有刺激性。溶解度:150 g/l 水 (20°C)，75 g/l 乙醇 (20°C)
应用
十二烷基硫酸钠被用作一种检测化合物，用于研究解淀粉芽孢杆菌KPS46是否能在大豆（Glycine max L.）中诱导针对几种疾病的引发、信号传导、蛋白质产生以及系统保护。
十二烷基硫酸钠（SDS）是一种阴离子去污剂，可通过疏水相互作用与蛋白质形成复合物。已有研究报道称蛋白质-SDS复合物的流体动力学功能受其多肽链长度的控制。因此，基于SDS的电泳技术可根据蛋白质的分子量而将蛋白质分子进行分离。此外，SDS还可溶解细胞膜并提取膜结合蛋白。
Sodium dodecyl sulfate (SDS), also known as sodium lauryl sulfate, is a versatile anionic surfactant with a broad range of applications in cell biology, biochemistry, and various industries. Its amphiphilic nature, characterized by a hydrophobic hydrocarbon tail and a hydrophilic sulfate head group, makes it an effective detergent capable of solubilizing and denaturing proteins, lipids, and other hydrophobic molecules.
In protein biochemistry, SDS plays a pivotal role in protein extraction and SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis). Its ability to denature proteins by disrupting their secondary and tertiary structures allows for their uniform migration through a polyacrylamide gel matrix based on their molecular weight. This technique, SDS-PAGE, has become an indispensable tool for analyzing protein size and purity.
Beyond protein analysis, SDS also finds applications in nucleic acid extraction and hybridization techniques. Its detergent properties aid in the lysis of cells and the solubilization of cellular components, facilitating the extraction of DNA and RNA. This makes SDS a valuable reagent in various molecular biology protocols, including PCR (polymerase chain reaction) and Southern blotting. Sodium dodecyl sulfate stands as a versatile and widely used surfactant with a diverse range of applications due to its ability to solubilize, denature, and separate biological molecules for cell biology and biochemical research.
规格
别名
SDS,月桂基硫酸钠,月桂基硫酸盐钠盐
英文别名
Monogen Y 100 | Cycloryl 21 | NALS | Quolac EX-UB | Lauryl sodium sulfate | sodiumdodecylsulfate | Conco Sulfate WAS | Duponol | Perlandrol L | Sipon PD | Solsol needles | Stepanol methyl dry aw | Maprofix WAC-LA | Duponol WAQE | Gardinol | Maprofix NEU |
规格或纯度
分子生物学级, ≥98.5%(GC)
英文名称
Sodium dodecyl sulfate
生化机理
十二烷基硫酸钠（SDS）是一种阴离子去污剂，可通过疏水相互作用与蛋白质形成复合物。已有研究报道称蛋白质-SDS复合物的流体动力学功能受其多肽链长度的控制。因此，基于SDS的电泳技术可根据蛋白质的分子量而将蛋白质分子进行分离。此外，SDS还可溶解细胞膜并提取膜结合蛋白。
储存条件
室温,干燥
运输条件
常规运输
纯度
≥98.5%(GC)
名称和识别符
PubChem SID
EC号
205-788-1
分子类型
小分子
IUPAC Name
sodium;dodecyl sulfate
INCHI
1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1
InChi Key
DBMJMQXJHONAFJ-UHFFFAOYSA-M
Smiles
[Na+].CCCCCCCCCCCCOS([O-])(=O)=O
Isomeric SMILES
CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+]
UN Number
Packing Group
III
分子量
288.38
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机酸及其衍生物 |
| 类（Class) | 有机硫酸及其衍生物 |
| 亚类（Subclass） | 硫酸酯 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 硫酸单酯 |
| 其他上位类（Alternative Parents） | 烷基硫酸盐 有机氧化合物 有机钠盐 有机氧化物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 脂肪族非环化合物 - 烷基硝酸酯 - 烃衍生物 - 有机碱金属盐 - 有机氧化物 - 有机氧化合物 - 有机盐 - 有机钠盐 - 有机氧化合物 - 磺酸酯 - 硫酸单酯 |
| 描述（Description） | 该化合物属于有机化合物中的硫酸单酯类。这类有机化合物含有硫酸单酯官能团，通用结构为ROS(O)(=O)=O（R=有机酰基）。 |
| 外部描述符（External Descriptors） | alkyl sulfate |
三维结构
交互式化学结构模型
关联靶点（人）
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
TSHR
Tclin
Thyroid stimulating hormone receptor
(29986 活性数据)
PPARG
Tclin
Peroxisome proliferator-activated receptor gamma
(15191 活性数据)
PPARA
Tclin
Peroxisome proliferator-activated receptor alpha
(9197 活性数据)
THRB
Tclin
Thyroid hormone receptor beta-1
(7926 活性数据)
CXCL8
Tchem
Interleukin-8
(642 活性数据)
GLA
Tclin
Alpha-galactosidase A
(5444 活性数据)
NR1H4
Tclin
Bile acid receptor FXR
(6228 活性数据)
EPHX2
Tchem
Epoxide hydratase
(3844 活性数据)
AKT1
Tchem
Serine/threonine-protein kinase AKT
(9192 活性数据)
Homo sapiens
(32628 活性数据)
HCT-116
(91556 活性数据)
Lymphoblastoid cell
(5959 活性数据)
LMNA
Tbio
Prelamin-A/C
(36751 活性数据)
RECQL
Tbio
ATP-dependent DNA helicase Q1
(5575 活性数据)
HPGD
Tchem
15-hydroxyprostaglandin dehydrogenase [NAD+]
(24926 活性数据)
GMNN
Tbio
Geminin
(128009 活性数据)
USP1
Tchem
Ubiquitin carboxyl-terminal hydrolase 1
(22556 活性数据)
关联靶点（其它种属）
Cruzipain (33337 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Pseudomonas aeruginosa (123386 活性数据)
Enterobacter cloacae (7976 活性数据)
Staphylococcus aureus (210822 活性数据)
Acinetobacter baumannii (41033 活性数据)
Escherichia coli (133304 活性数据)
Proteus mirabilis (3894 活性数据)
Mycobacterium tuberculosis (203094 活性数据)
Enterococcus faecalis (29875 活性数据)
Candida albicans (78123 活性数据)
Nakaseomyces glabratus (9108 活性数据)
Candida parapsilosis (8521 活性数据)
Rattus norvegicus (775804 活性数据)
RAW264.7 (28094 活性数据)
lef
Anthrax lethal factor (7585 活性数据)
GCN5
Histone acetyltransferase GCN5 (89 活性数据)
Luciferin 4-monooxygenase (66902 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
Steinernema feltiae (10 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
密度
1.01
敏感性
易吸湿
熔点
204-207°C
分子量
288.380 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count
0
氢键受体数Hydrogen Bond Acceptor Count
4
可旋转键计数Rotatable Bond Count
12
精确质量Exact Mass
288.137 Da
单同位素质量Monoisotopic Mass
288.137 Da
拓扑极表面积Topological Polar Surface Area
74.800 Ų
重原子数Heavy Atom Count
18
形式电荷Formal Charge
0
复杂度Complexity
249.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
2
安全和危险性（GHS）
信号词
危险
危险声明
H228: 易燃固体
H302: 吞食有害
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
H411: 对水生生物有毒并具有长期持续影响
预防措施声明
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。
P240: 地面/粘结容器和接收设备
P241: 使用防爆的[电气/通风/照明/.../]设备。
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P271: 仅在室外或通风良好的地方使用。
P273: 避免释放到环境中。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P391: 收集溢出物
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P332+P313: 如发生皮肤刺激：求医/就诊。
P337+P313: 如仍觉眼刺激：求医/就诊。
P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。
P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P501: 将内容物/容器处理到。。。
P302+P352+P312: 如皮肤沾染：用水充分清洗。如感觉不适，呼叫急救中心/医生。
P301+P312+P330: 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口
P304+P340+P312: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。如感觉不适，呼叫急救中心/医生。
Class
4.1
Merck Index
8636
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Probiotics, Prebiotics, and Postbiotics in Skin Care: Conceptual Distinctions, Mechanisms of Action, and Their Applications in the Care of Dry, Itchy, and Rough Skin
目录： 技术文章
Protective and Potential Reparative Mechanisms of Prinsepia utilis Seed Oil on the Skin Barrier: Fatty Acid Composition, Epidermal Lipid Metabolism, and Research Evidence
目录： 技术文章
Mechanism of Action of Porous Silica in Oil-Control Loose Powder: Pore Structure, Capillary Imbibition, and Surface Modification
目录： 技术文章
Structure, Stratum Corneum Distribution, and Stratum Corneum Conditioning Mechanism of Capryloyl Salicylic Acid: Barrier Effects and Safety Evaluation
目录： 技术文章
Gentiana Root Extract and Gentiopicroside: Chemical Composition, Antioxidant and Inflammation-Modulating Mechanisms, and Their Potential Effects on Skin Barrier Homeostasis
目录： 技术文章
Mechanisms by Which Fructan-Rich Ophiopogon japonicus Tuberous Root Extract Supports Skin Moisturization and Barrier Function
目录： 技术文章
Phase-Partitioning Principles, System Differences, and Application Selection in Phenol-Based DNA and RNA Extraction
目录： 技术文章
What Is “Plant Collagen”? Distinguishing Ingredient Types, Structural Differences, Production Methods, and Skincare Effects
目录： 技术文章
What Is Direct Compression? Process Characteristics, Suitability Criteria, and Excipient Selection
目录： 技术文章
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